Evidence map›Paper›PMID 30718413›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis.

Kareem L Graham, Bonnie J Werner, Kimberly M Moyer, Alycia K Patton, Charles R Krois, Hong Sik Yoo, Maria Tverskoy, Melissa LaJevic, Joseph L Napoli, Raymond A Sobel and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Review
  5. Lazy neutrophils - a lack of DGAT1 reduces the chemotactic activity of mouse neutrophils.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  6. Immunometabolic effects ofImmunometabolism (Cobham, Surrey) · 2024
    Review
  7. Article
  8. Review
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  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Kareem L GrahamDepartment of Physiology, Emory University School of Medicine, Atlanta, GA 30322; kareemlgraham@gmail.com ebutcher@stanford.edu.
Bonnie J WernerDepartment of Physiology, Emory University School of Medicine, Atlanta, GA 30322.
Kimberly M MoyerDepartment of Physiology, Emory University School of Medicine, Atlanta, GA 30322.
Alycia K PattonDepartment of Physiology, Emory University School of Medicine, Atlanta, GA 30322.
Charles R KroisGraduate Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720.
Hong Sik YooGraduate Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720.
Maria TverskoyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Melissa LaJevicPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304.
Joseph L NapoliGraduate Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720.
Raymond A SobelDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Brian A ZabelPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304.
Eugene C ButcherDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305; kareemlgraham@gmail.com ebutcher@stanford.edu.
Emory University · USStanford University · USUniversity of California, Berkeley · USPalo Alto Veterans Institute for Research · US

Funding

MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
TUMOR BIOLOGYT32CA009151 · NCI · STANFORD UNIVERSITY · PI CLEARY, MICHAEL L · 1985 to 2014
$5.5M
Intestinal Lymphocyte TraffickingR37AI047822 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI BUTCHER, EUGENE C · 2011 to 2020
$3.5M
Regulation of B Cell Identity and Lineage ProgressionR01AI081878 · NIAID · NATIONAL JEWISH HEALTH · PI HAGMAN, JAMES R. · 2010 to 2014
$1.9M
Rdh10 and retinoic acid effects on differentiationR01DK112754 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI NAPOLI, JOSEPH L · 2017 to 2021
$1.9M
Novel Mucosa-homing Dendritic Cell: Development, Trafficking and FunctionR01AI093981 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI BUTCHER, EUGENE C · 2012 to 2016
$1.8M
Retinoid HomeostasisR01DK102014 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI NAPOLI, JOSEPH L · 2015 to 2019
$1.7M
A Novel Tolergenic Dendritic Cell: Biology & Therapeutic PotentialR01DK084647 · NIDDK · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI BUTCHER, EUGENE C · 2009 to 2013
$1.5M
New Approaches to Combat CNS Inflammation: Targeting a Metabolic Enzyme in Demyelinating DiseaseI01BX004115 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI BRIAN A. ZABEL · 2019 to 2026
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BLRD VA I01 BX004115NCI NIH HHS T32 CA009151NIAID NIH HHS R01 AI081878NIAID NIH HHS R01 AI093981NIAID NIH HHS R37 AI047822NIAID NIH HHS T32 AI007290NIDDK NIH HHS R01 DK084647NIDDK NIH HHS R01 DK102014NIDDK NIH HHS R01 DK112754
6 · The paper itself

Abstract

The balance of effector versus regulatory T cells (Tregs) controls inflammation in numerous settings, including multiple sclerosis (MS). Here we show that memory phenotype CD4

Indexed as

AnimalsCentral Nervous SystemDiacylglycerol O-AcyltransferaseEncephalomyelitisGene Knockout TechniquesHumansInflammationMiceMultiple SclerosisTh17 CellsTh1 CellsT-Lymphocytes, RegulatoryTretinoinDgat1 protein, mouseDiacylglycerol O-AcyltransferaseTretinoinexperimental autoimmune encephalomyelitisimmunometabolismmultiple sclerosisneuroinflammationT regulatory cell

Identifiers

PMID30718413
PMCPMC6386656
OpenAlexW2911589803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.