ArticleProceedings of the National Academy of Sciences of the United States of America2019
CD4 receptor diversity in chimpanzees protects against SIV infection.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- RNA Virus Diversity, Cross-Species Transmission, and Molecular Constraints in Two Closely Related Rat Species.Integrative zoology · 2026Article
- CXCR4-tropic HIV-1 infection in an immunocompetent monkey model.Nature communications · 2026Article
- Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses.eLife · 2025Article
- Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors.Nature microbiology · 2025Article
- A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons.BMC immunology · 2023Article
- Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes.Physiological reviews · 2023Review
- Widespread extinctions of co-diversified primate gut bacterial symbionts from humans.Nature microbiology · 2023Article
- Genetic adaptations to SIV across chimpanzee populations.PLoS genetics · 2022Article
- The Gombe Ecosystem Health Project: 16 years of program evolution and lessons learned.American journal of primatology · 2022Review
- A balancing act between primate lentiviruses and their receptor.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Retroviral Restriction Factors and Their Viral Targets: Restriction Strategies and Evolutionary Adaptations.Microorganisms · 2020Review
- Evolutionary Arms Race between Virus and Host Drives Genetic Diversity in Bat Severe Acute Respiratory Syndrome-Related Coronavirus Spike Genes.Journal of virology · 2020Article
- A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV).Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Selective use of primate CD4 receptors by HIV-1.PLoS biology · 2019Article
- Ibalizumab, a Novel Monoclonal Antibody for the Management of Multidrug-Resistant HIV-1 Infection.Antimicrobial agents and chemotherapy · 2019Review
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Authors and funding
46 authors at 19 institutions in 9 countries.
Frederic Bibollet-RucheDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Ronnie M RussellDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Weimin LiuDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Guillaume B E Stewart-JonesVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Scott Sherrill-MixDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Yingying LiDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Gerald H LearnDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Andrew G SmithDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Marcos V P GondimDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Lindsey J PlenderleithInstitute of Evolutionary Biology, University of Edinburgh, EH9 3FL Edinburgh, United Kingdom.ORCID 0000-0003-1941-2876
Julie M DeckerDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294.
Juliet L EaslickDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.
Katherine S WetzelDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.
Ronald G CollmanDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Shilei DingDépartement de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du Centre Hospitalier de L'Université de Montréal, Montréal, QC H2X0A9, Canada.
Andrés FinziDépartement de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du Centre Hospitalier de L'Université de Montréal, Montréal, QC H2X0A9, Canada.
Ahidjo AyoubaRecherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34090 Montpellier, France.
Martine PeetersRecherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34090 Montpellier, France.
Fabian H LeendertzResearch Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, 13353 Berlin, Germany.
Joost van SchijndelDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Annemarie GoedmakersChimbo Foundation, 1011 PW Amsterdam, The Netherlands.
Els TonChimbo Foundation, 1011 PW Amsterdam, The Netherlands.
Christophe BoeschDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.ORCID 0000-0001-9538-7858
Hjalmar KuehlDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Mimi ArandjelovicDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Paula DieguezDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Mizuki MuraiDepartment of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Christelle ColinProjet Primates France, Centre de Conservation pour Chimpanzés, BP 36 Faranah, Republic of Guinea.
Kathelijne KoopsDepartment of Anthropology, University of Zurich, CH-8006 Zurich, Switzerland.
Sheri SpeedeSanaga-Yong Chimpanzee Rescue Center, In Defense of Animals-Africa, Portland, OR 97204.
Mary K GonderDepartment of Biology, Drexel University, Philadelphia, PA 19104.ORCID 0000-0003-4190-4682
Martin N MullerDepartment of Anthropology, University of New Mexico, Albuquerque, NM 87131.
Crickette M SanzDepartment of Anthropology, Washington University in St. Louis, St Louis, MO 63130.
David B MorganCongo Program, Wildlife Conservation Society, BP 14537 Brazzaville, Republic of the Congo.
Rebecca AtenciaTchimpounga Chimpanzee Rehabilitation Center, The Jane Goodall Institute-Congo, BP 1206 Pointe Noire, Republic of Congo.
Debby CoxTchimpounga Chimpanzee Rehabilitation Center, The Jane Goodall Institute-Congo, BP 1206 Pointe Noire, Republic of Congo.
Alex K PielSchool of Natural Sciences and Psychology, Liverpool John Moores University, L3 3AF Liverpool, United Kingdom.
Fiona A StewartSchool of Natural Sciences and Psychology, Liverpool John Moores University, L3 3AF Liverpool, United Kingdom.
Jean-Bosco N NdjangoDepartment of Ecology and Management of Plant and Animal Resources, Faculty of Sciences, University of Kisangani, BP 2012 Kisangani, Democratic Republic of the Congo.
Deus MjunguGombe Stream Research Centre, The Jane Goodall Institute, Kigoma, Tanzania.
Elizabeth V LonsdorfDepartment of Psychology, Franklin and Marshall College, Lancaster, PA 17604.
Anne E PuseyDepartment of Evolutionary Anthropology, Duke University, Durham, NC 27708.
Peter D KwongVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-3560-232X
Paul M SharpInstitute of Evolutionary Biology, University of Edinburgh, EH9 3FL Edinburgh, United Kingdom.
George M ShawDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Beatrice H HahnDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104; bhahn@pennmedicine.upenn.edu.
University of Pennsylvania · USMax Planck Institute for Evolutionary Anthropology · DECentre for Immunity, Infection and Evolution · GBCentre Hospitalier de l’Université de Montréal · CAInserm · FRLiverpool John Moores University · GBNational Institutes of Health · USUniversity of Alabama at Birmingham · USDrexel University · USDuke University · USFranklin & Marshall College · USLincoln Park Zoo · USRobert Koch Institute · DEThe Jane Goodall Institute · TZThe Jane Goodall Institute · USUniversité de Kisangani · CDUniversity of New Mexico · USUniversity of Zurich · CHWashington University in St. Louis · US
Funding
Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2012 to 2018
$204.7MNonhuman primate studies for development of a prototype HIV vaccine that induces broadly neutralizing antibodiesUM1AI144371 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2019 to 2025
$190.4MThe Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7MYNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI RENGARAJAN, JYOTHI · 1985 to 2011
$114.0MWNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GOLDBERG, ERWIN · 1999 to 2011
$79.1MVirus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6MVirus and Antibody Gene Sequencing CoreP01AI131251 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Kevin Wiehe · 2017 to 2026
$40.7MFirst-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5MMechanisms Of Humoral EvasionZIAAI005023 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHOU, TONGQING · 2009 to 2025
$18.6MTRAINING IN HIV PATHOGENESIST32AI007632 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, James L. Riley · 2000 to 2026
$10.6MOptimizing glycan shield coverage, germline B cell receptor binding and epitope diversity of V2-apex targeted HIV-1 Env immunogensR37AI150590 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Beatrice H Hahn · 2019 to 2026
$6.9MNatural SIV Reservoirs and Human Zoonotic RiskR01AI050529 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2001 to 2022
$6.1MCIHR 352417NCRR NIH HHS P51 RR000165NCRR NIH HHS P51 RR013986NIAID NIH HHS P01 AI131251NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI050529NIAID NIH HHS R01 AI058715NIAID NIH HHS R01 AI091595NIAID NIH HHS R01 AI120810NIAID NIH HHS R01 AI131331NIAID NIH HHS R33 AI133696NIAID NIH HHS R37 AI050529NIAID NIH HHS R37 AI150590NIAID NIH HHS R56 AI091516NIAID NIH HHS R61 AI133696NIAID NIH HHS T32 AI007632NIAID NIH HHS UM1 AI100645NIAID NIH HHS UM1 AI126620NIAID NIH HHS UM1 AI144371NIH HHS P51 OD011133
Abstract
Human and simian immunodeficiency viruses (HIV/SIVs) use CD4 as the primary receptor to enter target cells. Here, we show that the chimpanzee CD4 is highly polymorphic, with nine coding variants present in wild populations, and that this diversity interferes with SIV envelope (Env)-CD4 interactions. Testing the replication fitness of SIVcpz strains in CD4
Indexed as
AnimalsCD4 AntigensCD4-Positive T-LymphocytesEvolution, MolecularGenetic VariationHIVHumansPan troglodytesPolysaccharidesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral Envelope ProteinsCD4 AntigensPolysaccharidesViral Envelope ProteinsCD4chimpanzeeenvelope glycoproteinglycan restrictionSIV
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