Evidence map›Paper›PMID 30718402›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM.

Nina Ripin, Julien Boudet, Malgorzata M Duszczyk, Alexandra Hinniger, Michael Faller, Miroslav Krepl, Abhilash Gadi, Robert J Schneider, Jiří Šponer, Nicole C Meisner-Kober and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 68 citations in OpenAlex.

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  8. Advances in RNA modification in myocardial fibrosis (Review).International journal of molecular medicine · 2025
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  10. Journal of chemical information and modeling · 2025
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  12. The functional landscape of the human ubiquitinome.bioRxiv : the preprint server for biology · 2025
    Article
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  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Nina RipinDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland; nina.ripin@mol.biol.ethz.ch nicole.meisner-kober@sbg.ac.at frederic.allain@mol.biol.ethz.ch.ORCID 0000-0001-6099-6506
Julien BoudetDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Malgorzata M DuszczykDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Alexandra HinnigerNovartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
Michael FallerNovartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
Miroslav KreplInstitute of Biophysics, Czech Academy of Sciences, 612 65 Brno, Czech Republic.ORCID 0000-0002-9833-4281
Abhilash GadiDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.
Robert J SchneiderDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.ORCID 0000-0001-5807-5564
Jiří ŠponerInstitute of Biophysics, Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Nicole C Meisner-KoberNovartis Institutes for BioMedical Research, 4002 Basel, Switzerland; nina.ripin@mol.biol.ethz.ch nicole.meisner-kober@sbg.ac.at frederic.allain@mol.biol.ethz.ch.
Frédéric H-T AllainDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland; nina.ripin@mol.biol.ethz.ch nicole.meisner-kober@sbg.ac.at frederic.allain@mol.biol.ethz.ch.
ETH Zurich · CHNovartis (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate-rich elements (AU-rich elements; AREs). These are a major class of

Indexed as

3' Untranslated RegionsAU Rich ElementsCrystallography, X-RayDimerizationELAV-Like Protein 1ELAV ProteinsHumansMagnetic Resonance SpectroscopyRibonucleoside Diphosphate ReductaseRNA-Binding ProteinsRNA Recognition MotifTumor Suppressor Proteins3' Untranslated RegionsELAV-Like Protein 1ELAV ProteinsRibonucleoside Diphosphate Reductaseribonucleotide reductase M2RNA-Binding ProteinsRRM1 protein, humanTumor Suppressor Proteinscrystal structuredimerizationmultiple registerNMR spectroscopyRNA-binding protein

Identifiers

PMID30718402
PMCPMC6386705
OpenAlexW2911763618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.