Evidence map›Paper›PMID 30718391›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Ca

Alex D White, Fei Fang, Frédéric G Jean-Alphonse, Lisa J Clark, Hyun-Jung An, Hongda Liu, Yang Zhao, Shelley L Reynolds, Sihoon Lee, Kunhong Xiao and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Article
  3. ABEEM/MM Magnesium Force Field for Proteins and Aqueous Solutions.Interdisciplinary sciences, computational life sciences · 2026
    Article
  4. Review
  5. Article
  6. DimericeLife · 2025
    Article
  7. Review
  8. Review
  9. Biochemical features of the Cry4B toxin ofMalariaWorld journal · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Endosomal parathyroid hormone receptor signaling.American journal of physiology. Cell physiology · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Alex D WhiteDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Fei FangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Frédéric G Jean-AlphonseDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Lisa J ClarkDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Hyun-Jung AnDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Hongda LiuDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Yang ZhaoDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Shelley L ReynoldsDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Sihoon LeeDepartment of Internal Medicine and Laboratory of Molecular Endocrinology, Gachon University School of Medicine, Incheon 21565, South Korea.
Kunhong XiaoDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; khxiao@pitt.edu ies4@pitt.edu jpv@pitt.edu.
Ieva SutkeviciuteDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; khxiao@pitt.edu ies4@pitt.edu jpv@pitt.edu.
Jean-Pierre VilardagaDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; khxiao@pitt.edu ies4@pitt.edu jpv@pitt.edu.ORCID 0000-0002-1217-1435
University of Pittsburgh · USGachon University · KR

Funding

Structure and function of PTH class B GPCRR01DK116780 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ivet Bahar, Jean-Pierre Vilardaga · 2018 to 2026
$4.2M
PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM008424 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAGANO, PATRICK J · 1994 to 2019
$3.4M
Functional Polarity of PTH Receptor Signaling: Cellular and Molecular MechanismsR01DK111427 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIEDMAN, PETER A, VILARDAGA, JEAN-PIERRE · 2017 to 2020
$2.4M
Structural and Functional Mechanisms of PTH-Receptor SignalingR01DK102495 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALERO, GUILLERMO ALBERTO, GARDELLA, THOMAS J · 2014 to 2017
$2.0M
NIDDK NIH HHS R01 DK102495NIDDK NIH HHS R01 DK111427NIDDK NIH HHS R01 DK116780NIGMS NIH HHS T32 GM008424
6 · The paper itself

Abstract

The parathyroid hormone (PTH) and its related peptide (PTHrP) activate PTH receptor (PTHR) signaling, but only the PTH sustains G

Indexed as

Allosteric RegulationAnimalsCalcium SignalingChlorocebus aethiopsCOS CellsCyclic AMPHumansHypocalcemiaKineticsLigandsParathyroid HormoneParathyroid Hormone-Related ProteinPoint MutationProtein BindingReceptor, Parathyroid Hormone, Type 1Cyclic AMPLigandsParathyroid HormoneParathyroid Hormone-Related ProteinReceptor, Parathyroid Hormone, Type 1Ca2+ allosterismendosomal cAMP signalingGPCR signalingPTHPTH receptor

Identifiers

PMID30718391
PMCPMC6386702
OpenAlexW2913698238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.