ArticleInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society2019
The association between histological subtype of a first primary endometrial cancer and second cancer risk.
Article in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 13 citations in OpenAlex.
- Endometrial Carcinoma Unveiling Breast Carcinoma in a Postmenopausal Female: A Case of Synchronous Malignancy.Ochsner journal · 2026Article
- Trends in endometrial cancer incidence in the United States by race/ethnicity and age of onset from 2000 to 2019.American journal of epidemiology · 2025Article
- Global burden and trends in pre- and post-menopausal gynecological cancer from 1990 to 2019, with projections to 2040: a cross-sectional study.International journal of surgery (London, England) · 2025Article
- Nomograms for Predicting Overall and Cancer-Specific Survival Among Second Primary Endometrial Cancer in Primary Colorectal Carcinoma Patients.Risk management and healthcare policy · 2024Article
- Causes of death in endometrial cancer survivors: A Surveillance, Epidemiology, and End Result-based analysis.Cancer medicine · 2023Article
- Survival for endometrial cancer as a second primary malignancy.Cancer medicine · 2022Article
- Increased risk of second primary malignancies among endometrial cancer survivors receiving surgery alone: A population-based analysis.Cancer medicine · 2021Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the risk of a second primary cancer after endometrial cancer according to histological subtype.
methodsUsing data from the 13 National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registries we identified women diagnosed with a primary endometrial cancer between 1992 and 2014. We calculated standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for second primary cancer risk (all anatomical sites combined and for individual anatomical sites) among patients with endometrial cancer compared with the general population, in the overall study population and according to histological subtype.
resultsAmong 96 256 women diagnosed with endometrial cancer, 8.4% (n=8083) developed a second primary cancer. The risk of second primary cancer was higher among patients with endometrial cancer than in the general population (SIR=1.05, 95% CI 1.03 to 1.07). We observed significantly higher second primary cancer risk among women with high grade endometrioid (SIR=1.12, 95% CI 1.05 to 1.19), serous (SIR=1.24, 95% CI 1.11 to 1.38), carcinosarcoma (SIR=1.18, 95% CI 1.02 to 1.35), mixed epithelial (SIR=1.22, 95% CI 1.06 to 1.40), and sarcoma (SIR=1.28, 95% CI 1.12 to 1.45) compared with the general population, but not for women with low grade endometrioid (SIR=1.01, 95% CI 0.98 to 1.03) or clear cell (SIR=1.09, 95% CI 0.88 to 1.33) endometrial cancer. Women with low grade endometrioid endometrial cancer had significantly lower second primary cancer risks in the gum and other mouth (SIR=0.57, 95% CI 0.30 to 0.97), lung and bronchus (SIR=0.72, 95% CI 0.66 to 0.77), and lymphocytic leukemia (SIR=0.71, 95% CI 0.54 to 0.93) while women with high risk endometrial cancer histological subtypes experienced significantly higher second primary cancer risk at several anatomical sites.
conclusionsRisk of developing second primary cancersat all anatomic sites combined and at individual anatomical sites varied according to histological subtype. Clinicians should be aware that women with different histological subtypes carry different second primary cancer risks .
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