Evidence map›Paper›PMID 30718297›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic

Carleigh A O'Brien, Samantha J Batista, Katherine M Still, Tajie H Harris

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. CD4Malaria journal · 2022
    Article
  6. Article
  7. Article
  8. ICOSFrontiers in immunology · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Carleigh A O'BrienCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908.
Samantha J BatistaCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908.
Katherine M StillCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908.
Tajie H HarrisCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908 tajieharris@virginia.edu.ORCID 0000-0002-1355-2109
University of Virginia · US

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
PREDOCTORAL TRAINING IN NEUROSCIENCET32GM008328 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LEE, KEVIN SCOTT · 1992 to 2017
$3.9M
Regulatory T cell responses in T. gondii infection of the brainR01NS091067 · NINDS · UNIVERSITY OF VIRGINIA · PI HARRIS, TAJIE H. · 2015 to 2019
$1.8M
NIAID NIH HHS T32 AI007046NIAID NIH HHS T32 AI007496NIGMS NIH HHS T32 GM008328NINDS NIH HHS R01 NS091067
6 · The paper itself

Abstract

Control of chronic CNS infection with the parasite

Indexed as

AnimalsBrainInducible T-Cell Co-Stimulator ProteinInterleukin-10Lymphocyte ActivationMiceMice, Inbred C57BLT-LymphocytesToxoplasmosisIcos protein, mouseIL10 protein, mouseInducible T-Cell Co-Stimulator ProteinInterleukin-10

Identifiers

PMID30718297
PMCPMC6401250
OpenAlexW2950168042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.