Evidence map›Paper›PMID 30718252›Full record

ArticleAntimicrobial agents and chemotherapy2019

Negative Impact of Carbapenem Methylation on the Reactivity of β-Lactams for Cysteine Acylation as Revealed by Quantum Calculations and Kinetic Analyses.

Nicholus Bhattacharjee, Sébastien Triboulet, Vincent Dubée, Matthieu Fonvielle, Zainab Edoo, Jean-Emmanuel Hugonnet, Mélanie Ethève-Quelquejeu, Jean-Pierre Simorre, Martin J Field, Michel Arthur and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Competing off-loading mechanisms of meropenem from an l,d-transpeptidase reduce antibiotic effectiveness.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Nicholus Bhattacharjee *Université Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
Sébastien Triboulet *Sorbonne Université, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, INSERM, Centre de Recherche des Cordeliers, CRC, Paris, France.
Vincent DubéeSorbonne Université, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, INSERM, Centre de Recherche des Cordeliers, CRC, Paris, France.
Matthieu FonvielleSorbonne Université, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, INSERM, Centre de Recherche des Cordeliers, CRC, Paris, France.
Zainab EdooSorbonne Université, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, INSERM, Centre de Recherche des Cordeliers, CRC, Paris, France.
Jean-Emmanuel HugonnetSorbonne Université, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, INSERM, Centre de Recherche des Cordeliers, CRC, Paris, France.
Mélanie Ethève-QuelquejeuUniversité Paris Descartes, CNRS UMR 8601, Paris, France.
Jean-Pierre SimorreUniversité Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
Martin J FieldUniversité Grenoble Alpes, CNRS, CEA, BIG, LCBM (UMR 5249), Grenoble, France.
Michel Arthur *Sorbonne Université, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot, INSERM, Centre de Recherche des Cordeliers, CRC, Paris, France michel.arthur@crc.jussieu.fr catherine.bougault@ibs.fr.
Catherine M Bougault *Université Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France michel.arthur@crc.jussieu.fr catherine.bougault@ibs.fr.
Université Paris Cité · FRCentre de Recherche des Cordeliers · FRUniversité Grenoble Alpes · FRCEA Grenoble · FRCentre National de la Recherche Scientifique · FRSorbonne Paris Cité · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

AcylationAnti-Bacterial AgentsCarbapenemsCatalytic DomainCysteineEnterococcus faeciumMethylationPeptidoglycanPeptidyl TransferasesAnti-Bacterial AgentsCarbapenemsCysteinePeptidoglycanPeptidyl Transferasesconcerted β-lactam ring openingcysteine acylationDFT mechanistic investigationsl,d-transpeptidaseβ-lactam

Identifiers

PMID30718252
PMCPMC6437502
OpenAlexW2913287152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.