Evidence map›Paper›PMID 30718242›Full record

ArticleBlood advances2019

Malglycemia is associated with poor outcomes in pediatric and adolescent hematopoietic stem cell transplant patients.

Jenna Sopfe, Laura Pyle, Amy K Keating, Kristen Campbell, Arthur K Liu, R Paul Wadwa, Michael R Verneris, Roger H Giller, Gregory P Forlenza

Abstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jenna SopfeBone Marrow Transplant Program, Center for Cancer and Blood Disorders, Department of Pediatrics, and.ORCID 0000-0001-5191-7511
Laura PyleDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO.ORCID 0000-0001-5577-8221
Amy K KeatingBone Marrow Transplant Program, Center for Cancer and Blood Disorders, Department of Pediatrics, and.
Kristen CampbellDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO.ORCID 0000-0002-3675-2533
Arthur K LiuDepartment of Radiation Oncology and.ORCID 0000-0001-5784-048X
R Paul WadwaBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO.ORCID 0000-0002-4139-2122
Michael R VernerisBone Marrow Transplant Program, Center for Cancer and Blood Disorders, Department of Pediatrics, and.ORCID 0000-0002-7097-5917
Roger H GillerBone Marrow Transplant Program, Center for Cancer and Blood Disorders, Department of Pediatrics, and.ORCID 0000-0003-4588-7111
Gregory P ForlenzaBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO.ORCID 0000-0003-3607-9788

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
K12 Career DevelopmentK12DK094712 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI STECK, ANDREA · 2011 to 2021
$4.5M
NCATS NIH HHS UL1 TR001082NIDDK NIH HHS K12 DK094712
6 · The paper itself

Abstract

Malglycemia (hypoglycemia, hyperglycemia, and/or glycemic variability) in adult hematopoietic stem cell transplant (HSCT) recipients is associated with increased infection, graft-versus-host disease, organ dysfunction, delayed engraftment, and mortality. Malglycemia has not been studied in pediatric HSCT recipients. This study aimed to characterize the incidence and consequences of malglycemia in this population. Medical records for a cohort of 344 patients, age 0 to 30 years, who underwent first HSCT from 2007 to 2016 at Children's Hospital Colorado were retrospectively reviewed. Glucose data were analyzed in intervals and assessed for potential risk factors and associated outcomes. Malglycemia occurred in 43.9% of patients. Patients with a day 0 to 100 mean glucose of 100 to 124 mg/dL had a 1.76-fold (95% confidence interval [CI], 1.10-2.82;

Indexed as

AdolescentChildChild, PreschoolFemaleHematopoietic Stem Cell TransplantationHumansHyperglycemiaHypoglycemiaInfantInfant, NewbornMaleRisk FactorsTransplantation ConditioningTreatment Outcome

Identifiers

PMID30718242
PMCPMC6373732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.