SynthesisBritish journal of sports medicine2019
Clinical risk factors for Achilles tendinopathy: a systematic review.
Synthesis in British journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Pooled it
- Associations ofAging · 2024Pooled it
- Pooled it
- Extracorporeal Shockwave Therapy for Mid-portion and Insertional Achilles Tendinopathy: A Systematic Review of Randomized Controlled Trials.Sports medicine - open · 2022Pooled it
- Association of COL5A1 gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis based on 21 observational studies.Journal of orthopaedic surgery and research · 2022Pooled it
- Fluoroquinolones and the risk of tendon injury: a systematic review and meta-analysis.European journal of clinical pharmacology · 2019Pooled it
- Topical glyceryl trinitrate (GTN) and eccentric exercises in the treatment of mid-portion achilles tendinopathy (the NEAT trial): a randomised double-blind placebo-controlled trial.British journal of sports medicine · 2024Trial
- Patterns of movement-evoked pain during tendon loading and stretching tasks in Achilles tendinopathy: A secondary analysis of a randomized controlled trial.Clinical biomechanics (Bristol, Avon) · 2023Trial
- Trial
- Lower limb neuromotor control during perturbed and unperturbed gait conditions in male runners with Achilles tendinopathy: an exploratory analysis.International biomechanics · 2026Article
- Achilles Tendinopathy: Comorbidity Profile and Incidence From the TriNetX Network.Medical research archives · 2026Article
- Complications and outcomes following surgical management of common calcaneal tendon pathology in 80 dogs.Veterinary surgery : VS · 2026Article
- Adolescent health behaviors, family socioeconomic status and health as risk factors for tendon ruptures in adulthood: a longitudinal study.BMC musculoskeletal disorders · 2025Article
- Feasibility of a UTE Stack-of-Spirals Sequence for TNMR in biomedicine · 2025Article
- Fluoroquinolone-Induced Achilles Tendon Damage: Structural and Biochemical Insights into Collagen Type I Alterations.International journal of molecular sciences · 2025Review
- Exercise parameters to consider for Achilles tendinopathy: a modified Delphi study with international experts.British journal of sports medicine · 2025Article
- Nonlinear Interactions of Lower Limb Clinical Measures Associated With Asymptomatic Achilles Tendon Abnormality in Ballet Dancers.Journal of athletic training · 2025Article
- Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Achilles tendinopathy.Nature reviews. Disease primers · 2025Review
- Effects of Autologous Tenocyte Injection for Overuse and Degenerative Tendinopathies: A Systematic Review.Journal of functional morphology and kinesiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAchilles tendinopathy is a common problem, but its exact aetiology remains unclear.
objectiveTo evaluate the association between potential clinical risk factors and Achilles tendinopathy.
designSystematic review. DATA SOURCES: The databases Embase, MEDLINE Ovid, Web of Science, Cochrane Library and Google Scholar were searched up to February 2018. ELIGIBILITY CRITERIA: To answer our research question, cohort studies investigating risk factors for Achilles tendinopathy in humans were included. We restricted our search to potential clinical risk factors (imaging studies were excluded).
resultsWe included 10 cohort studies, all with a high risk of bias, from 5111 publications identified. There is limited evidence for nine risk factors: (1) prior lower limb tendinopathy or fracture, (2) use of ofloxacin (quinolone) antibiotics, (3) an increased time between heart transplantation and initiation of quinolone treatment for infectious disease, (4) moderate alcohol use, (5) training during cold weather, (6) decreased isokinetic plantar flexor strength, (7) abnormal gait pattern with decreased forward progression of propulsion, (8) more lateral foot roll-over at the forefoot flat phase and (9) creatinine clearance of <60 mL/min in heart transplant patients. Twenty-six other putative risk factors were not associated with Achilles tendinopathy, including being overweight, static foot posture and physical activity level.
conclusionFrom an ocean of studies with high levels of bias, we extracted nine clinical risk factors that may increase a person's risk of Achilles tendinopathy. Clinicians may consider ofloxacin use, alcohol consumption and a reduced plantar flexor strength as modifiable risk factors when treating patients with Achilles tendinopathy. TRIAL REGISTRATION NUMBER: CRD42017053258.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.