ArticleMolecular metabolism2019
Transcriptional and physiological roles for STAT proteins in leptin action.
Article in Molecular metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- G Protein-Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models.Obesity (Silver Spring, Md.) · 2026Review
- Increased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity.Molecular metabolism · 2026Article
- The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition.Nature communications · 2026Article
- Central leptin pathways in metabolic homeostasis.Clinical science (London, England : 1979) · 2025Review
- Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity.The Journal of biological chemistry · 2025Review
- Molecular mechanisms and neural mediators of leptin action.Genes & development · 2025Review
- Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies.International journal of molecular sciences · 2023Review
- Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake.International journal of molecular sciences · 2023Review
- STAT3 phosphorylation in central leptin resistance.Nutrition & metabolism · 2021Review
- The Adipokine Component in the Molecular Regulation of Cancer Cell Survival, Proliferation and Metastasis.Pathology oncology research : POR · 2021Review
- High-Fat Diet-Related Obesity Promotes Urethane-Induced Lung Tumorigenesis in C57BL/6J Mice.Frontiers in oncology · 2021Article
- Adipocyte-Derived Leptin Promotes PAI-1 -Mediated Breast Cancer Metastasis in a STAT3/miR-34a Dependent Manner.Cancers · 2020Article
- Identification of the leptin receptor sequences crucial for the STAT3-Independent control of metabolism.Molecular metabolism · 2020Article
- Characterization and Treatment of Inflammation and Insulin Resistance in Obese Adipose Tissue.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Central growth hormone action regulates metabolism during pregnancy.American journal of physiology. Endocrinology and metabolism · 2019Article
- Luciferase Reporter Mice forJournal of the Endocrine Society · 2019Article
- Article
- Variability in the leptin receptor gene and other risk factors for post-transplant diabetes mellitus in renal transplant recipients.Annals of medicine · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectivesLeptin acts via its receptor LepRb on specialized neurons in the brain to modulate food intake, energy expenditure, and body weight. LepRb activates signal transducers and activators of transcription (STATs, including STAT1, STAT3, and STAT5) to control gene expression.
methodsBecause STAT3 is crucial for physiologic leptin action, we used TRAP-seq to examine gene expression in LepRb neurons of mice ablated for Stat3 in LepRb neurons (Stat3
resultsWhile we also found increased Stat1 expression and STAT1-mediated transcription of leptin-regulated genes in Stat3
conclusionsThus, STAT3 represents the unique STAT protein required for leptin action and STAT3 suffices to mediate important components of leptin action in the absence of other LepRb signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.