Trial reportBiological psychiatry2019
Pretreatment Rostral Anterior Cingulate Cortex Connectivity With Salience Network Predicts Depression Recovery: Findings From the EMBARC Randomized Clinical Trial.
Trial report in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03998748 (Electrophysiological Correlates of Cognition in Depression), which is not on this map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electrophysiological Correlates of Cognition in Depression
Who cites it
42 citing papers in PubMed, 68 citations in OpenAlex.
- Subtyping depression using brain-gastric electrophysiology for early prediction of antidepressant response: a multicentric clinical study.Frontiers in psychiatry · 2026Trial
- Expectancy-Mood Neural Dynamics Predict Mechanisms of Short- and Long-Term Antidepressant Placebo Effects.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Trial
- A common symptom geometry of mood improvement under sertraline and placebo associated with distinct neural patterns.Psychological medicine · 2025Trial
- Individualized fMRI connectivity defines signatures of antidepressant and placebo responses in major depression.Molecular psychiatry · 2023Trial
- Rostral anterior cingulate network effective connectivity in depressed adolescents and associations with treatment response in a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder.Molecular psychiatry · 2020Trial
- Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression.Human brain mapping · 2020Trial
- Article
- Modulatory effects of ketamine on EEG source-based resting state connectivity in treatment resistant depression.Translational psychiatry · 2026Article
- Relationships between local metabolic activity and distributed functional connectivity in major depressive disorder.Translational psychiatry · 2025Article
- Differences in High-Frequency Connectivity Among Large-Scale Functional Networks Linked to Major Depressive Disorder and Treatment-Resistant Depression.Biological psychiatry global open science · 2025Article
- Early treatment-related changes in dorsolateral prefrontal cortex activity and functional connectivity as potential biomarkers for antidepressant response in major depressive disorder.Translational psychiatry · 2025Article
- Initial evidence for neural correlates following a therapeutic intervention: altered resting state functional connectivity in the default mode network following attention training technique.Frontiers in psychiatry · 2025Article
- Smoking Progression and Nicotine-Enhanced Reward Sensitivity Predicted by Resting-State Functional Connectivity in Salience and Executive Control Networks.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Observational
- Task-induced deactivation dysfunction during reward processing is associated with low self-esteem in a possible subtype of major depression.Brain and behavior · 2024Article
- Individual deviations from normative electroencephalographic connectivity predict antidepressant response.Journal of affective disorders · 2024Article
- Effectiveness of non-invasive brain stimulation on depressive symptoms targeting prefrontal cortex in functional magnetic resonance imaging studies: a combined systematic review and meta-analysis.Psychoradiology · 2024Review
- Altered task-related decoupling of the rostral anterior cingulate cortex in depression.NeuroImage. Clinical · 2024Article
- Prediction of pharmacological treatment efficacy using electroencephalography-based salience network in patients with major depressive disorder.Frontiers in psychiatry · 2024Article
- Insula-cingulate structural and functional connectivity: an ultra-high field MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundBaseline rostral anterior cingulate cortex (rACC) activity is a well-replicated nonspecific predictor of depression improvement. The rACC is a key hub of the default mode network, which prior studies indicate is hyperactive in major depressive disorder. Because default mode network downregulation is reliant on input from the salience network and frontoparietal network, an important question is whether rACC connectivity with these systems contributes to depression improvement.
methodsOur study evaluated this hypothesis in outpatients (N = 238; 151 female) enrolled in the Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) 8-week randomized clinical trial of sertraline versus placebo for major depressive disorder. Depression severity was measured using the Hamilton Rating Scale for Depression, and electroencephalography was recorded at baseline and week 1. Exact low-resolution electromagnetic tomography was used to compute activity from the rACC, and key regions within the default mode network (posterior cingulate cortex), frontoparietal network (left dorsolateral prefrontal cortex), and salience network (right anterior insula [rAI]). Connectivity in the theta band (4.5-7 Hz) and beta band (12.5-21 Hz) was computed using lagged phase synchronization.
resultsStronger baseline theta-band rACC-rAI (salience network hub) connectivity predicted greater depression improvement across 8 weeks of treatment for both treatment arms (B = -0.57, 95% confidence interval = -1.07, -0.08, p = .03). Early increases in theta-band rACC-rAI connectivity predicted greater likelihood of achieving remission at week 8 (odds ratio = 2.90, p = .03).
conclusionsAmong patients undergoing treatment, theta-band rACC-rAI connectivity is a prognostic, albeit treatment-nonspecific, indicator of depression improvement, and early connectivity changes may predict clinically meaningful outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.