Evidence map›Paper›PMID 30717885›Full record

ArticleThe American journal of cardiology2019

Usefulness of Left Ventricular Strain by Cardiac Magnetic Resonance Feature-Tracking to Predict Cardiovascular Events in Patients With and Without Heart Failure.

Mayank Sardana, Prasad Konda, Zeba Hashmath, Garrett Oldland, Swetha Gaddam, Rachana Miller, Vaibhav Satija, Bilal Ansari, Jonathan Lee, Anique Mustafa and 2 more

Abstract read
In one paragraph

Article in The American journal of cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  7. Right ventricular function declines prior to left ventricular ejection fraction in hypertrophic cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
  8. Comparing cardiovascular magnetic resonance strain software packages by their abilities to discriminate outcomes in patients with heart failure with preserved ejection fraction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
  9. Layer-specific strain in patients with heart failure using cardiovascular magnetic resonance: not all layers are the same.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Article
  10. Detection of subclinical myocardial dysfunction in cocaine addicts with feature tracking cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Mayank SardanaUniversity of California San Francisco, San Francisco, California.
Prasad KondaPerelman Center for Advanced Medicine, Philadelphia, Pennsylvania; Mercy Catholic Medical Center, Drexel University College of Medicine, Philadelphia, Pennsylvania.
Zeba HashmathPerelman Center for Advanced Medicine, Philadelphia, Pennsylvania.
Garrett OldlandPerelman Center for Advanced Medicine, Philadelphia, Pennsylvania; Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania.
Swetha GaddamPerelman Center for Advanced Medicine, Philadelphia, Pennsylvania; Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania.
Rachana MillerPerelman Center for Advanced Medicine, Philadelphia, Pennsylvania; Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania.
Vaibhav SatijaPerelman Center for Advanced Medicine, Philadelphia, Pennsylvania.
Bilal AnsariPerelman Center for Advanced Medicine, Philadelphia, Pennsylvania.
Jonathan LeePerelman Center for Advanced Medicine, Philadelphia, Pennsylvania.
Anique MustafaPerelman Center for Advanced Medicine, Philadelphia, Pennsylvania.
Scott R AkersCorporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania.
Julio A ChirinosPerelman Center for Advanced Medicine, Philadelphia, Pennsylvania; Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania. Electronic address: Julio.chirinos@uphs.upenn.edu.
Philadelphia VA Medical Center · USMercy Catholic Medical Center · USUniversity of California, San Francisco · US

Funding

Efficacy of Potassium Nitrate in Heart Failure with Preserved Ejection FractionR01HL121510 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2015 to 2019
$3.1M
Targeting Central Pulsatile Hemodynamics in Chronic Kidney DiseaseR56HL124073 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2015 to 2015
$594k
Targeting Wave Reflections in Heart Failure with Preserved Ejection FractionR21AG043802 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2013 to 2014
$440k
NHLBI NIH HHS R01 HL121510NHLBI NIH HHS R56 HL124073NIA NIH HHS R21 AG043802
6 · The paper itself

Abstract

There is controversy regarding the utility of left ventricular (LV) mechanics assessed by feature-tracking steady-state free-precession (FT-SSFP), a readily implementable technique in clinical practice. In particular, whether LV mechanics assessed by FT-SSFP predicts outcomes in subjects with heart failure (HF) with reduced ejection fraction (HFrEF), with preserved ejection fraction (HFpEF), or without HF is unknown. We aimed to assess whether LV mechanics measured with FT-SSFP cine magnetic resonance imaging (MRI) predicts adverse outcomes. We prospectively enrolled 612 adults without HF (n = 402), with HF with reduced ejection fraction (HFrEF; n = 113), or HFpEF (n = 97) and assessed LV strain using FT-SSFP cine MRI. Over a median follow-up of 39.5 months, 75 participants had an HF admission, and 85 died. In Cox proportional hazards models, lower global longitudinal (Standardized hazard ratio 1.56, 95% confidence interval [CI] 1.22 to 2.00, p = 0.0004), circumferential (Standardized HR 1.46, 95% CI 1.08 to 1.95, p = 0.0123), and radial strain (Standardized HR 0.59, 95% CI 0.43 to 0.83, p = 0.0019) were independently associated with the composite endpoint, after adjustment for HF status, LV ejection fraction (LVEF), age, sex, ethnicity, body mass index, systolic and diastolic blood pressure, hypertension, diabetes, coronary artery disease, and glomerular filtration rate. Furthermore, global longitudinal strain stratified the risk of adverse outcomes across tertiles better than LVEF. In analyses that included only participants with a preserved LVEF, systolic radial, circumferential and longitudinal strain were independently predictive of adverse outcomes. We conclude that LV longitudinal, circumferential and radial strain measured using FT-SSFP cine MRI (a readily implementable technique in clinical practice) predict the risk of adverse events, independently of LVEF.

Indexed as

AgedFemaleFollow-Up StudiesHeart FailureHeart VentriclesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedPredictive Value of TestsProspective StudiesStroke VolumeVentricular Function, Left

Identifiers

PMID30717885
PMCPMC6435378
OpenAlexW2913322849

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.