ArticleeLife2019
Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Neural correlates of phantom motor execution: A functional neuroimaging systematic review and meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Pooled it
- Human perceptual learning is delayed by the N-methyl-D-aspartate receptor partial agonist D-cycloserine.Journal of psychopharmacology (Oxford, England) · 2021Trial
- Cutting a nerve of the hand alters the organization of digit maps in primary somatosensory cortex.Nature human behaviour · 2026Article
- On the impact of tactile processing on motor cortex: how touch shapes motor behaviour.Brain structure & function · 2026Review
- Global remapping of the sensory homunculus emerges early in childhood development.Nature communications · 2026Article
- Stable cortical body maps before and after arm amputation.Nature neuroscience · 2025Article
- TMS-Based Neurofeedback Training of Mental Finger Individuation Induces Neuroplastic Changes in the Sensorimotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Functional and Structural Neural Plasticity Following sEMG Control of a Virtual Prosthetic Hand in an Individual with Bilateral Upper-Limb Congenital Amputation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A Roadmap for Implanting Electrode Arrays to Evoke Tactile Sensations Through Intracortical Stimulation.Human brain mapping · 2024Article
- A preliminary study exploring the effects of transcutaneous spinal cord stimulation on spinal excitability and phantom limb pain in people with a transtibial amputation.Journal of neural engineering · 2024Article
- A roadmap for implanting microelectrode arrays to evoke tactile sensations through intracortical microstimulation.medRxiv : the preprint server for health sciences · 2024Article
- Does Ipsilateral Remapping Following Hand Loss Impact Motor Control of the Intact Hand?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Moving a missing hand: children born with below elbow deficiency can enact hand grasp patterns with their residual muscles.Journal of neuroengineering and rehabilitation · 2024Article
- The importance of brain mapping for rehabilitation in birth nonprogressive neuromuscular diseases.Frontiers in neuroimaging · 2024Review
- Against cortical reorganisation.eLife · 2023Article
- Similar somatotopy for active and passive digit representation in primary somatosensory cortex.Human brain mapping · 2023Article
- Complex pattern of facial remapping in somatosensory cortex following congenital but not acquired hand loss.eLife · 2022Article
- Article
- Preserved cortical somatotopic and motor representations in tetraplegic humans.Current opinion in neurobiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
A key question in neuroscience is how cortical organisation relates to experience. Previously we showed that amputees experiencing highly vivid phantom sensations maintain cortical representation of their missing hand (Kikkert et al., 2016). Here, we examined the role of sensory hand experience on persistent hand representation by studying individuals with acquired and congenital hand loss. We used representational similarity analysis in primary somatosensory and motor cortex during missing and intact hand movements. We found that key aspects of acquired amputees' missing hand representation persisted, despite varying vividness of phantom sensations. In contrast, missing hand representation of congenital one-handers, who do not experience phantom sensations, was significantly reduced. Across acquired amputees, individuals' reported motor control over their phantom hand positively correlated with the extent to which their somatosensory hand representation was normally organised. We conclude that once cortical organisation is formed, it is remarkably persistent, despite long-term attenuation of peripheral signals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.