ArticleBMC veterinary research2019
Susceptibility breakpoint for Danofloxacin against swine Escherichia coli.
Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- 2002-2022 Quinolone Resistance inVeterinary sciences · 2025Review
- Evaluation of the mutant selection window of danofloxacin againstFrontiers in veterinary science · 2023Article
- Epidemiological Cut-Off Values and Multidrug Resistance ofAnimals : an open access journal from MDPI · 2022Article
- Clinical Breakpoint of Apramycin to SwineInternational journal of molecular sciences · 2022Article
- Comparison of PK/PD Targets and Cutoff Values for Danofloxacin AgainstFrontiers in veterinary science · 2022Article
- Pharmacokinetic Behavior and Pharmacokinetic/Pharmacodynamic Integration of Danofloxacin Following Single or Co-Administration with Meloxicam in Healthy Lambs and Lambs with Respiratory Infections.Antibiotics (Basel, Switzerland) · 2021Article
- Exploration of Clinical Breakpoint of Danofloxacin forAntibiotics (Basel, Switzerland) · 2021Article
- Research Note: Epidemiological cutoff values and acquired resistance mechanisms of three veterinary antibiotics against Escherichia coli from chicken respiratory tract infections.Poultry science · 2021Article
- Wild-type cutoff for Apramycin against Escherichia coli.BMC veterinary research · 2020Article
- The prevalence and mechanism of fluoroquinolone resistance in Escherichia coli isolated from swine farms in China.BMC veterinary research · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundImproper use of antimicrobials results in poor treatment and severe bacterial resistance. Breakpoints are routinely used in the clinical laboratory setting to guide clinical decision making. Therefore, the objective of this study was to establish antimicrobial susceptibility breakpoints for danofloxacin against Escherichia coli (E.coli), which is an important pathogen of digestive tract infections.
resultsThe minimum inhibitory concentrations (MICs) of 1233 E. coli isolates were determined by the microdilution broth method in accordance with the guidelines in Clinical and Laboratory Standards Institute (CLSI) document M07-A9. The wild type (WT) distribution or epidemiologic cutoff value (ECV) was set at 8 μg/mL with statistical analysis. Plasma drug concentration data were used to establish pharmacokinetic (PK) model in swine. The in vitro time kill test in our study demonstrated that danofloxacin have concentration dependent activity against E.coli. The PK data indicated that danofloxacin concentration in plasma was rapidly increased to peak levels at 0.97 h and remained detectable until 48 h after drug administration. The pharmacodynamic cutoff (CO
conclusionsCompared to the CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.