ArticleBMC complementary and alternative medicine2019
Decreased fracture incidence with traditional Chinese medicine therapy in patients with osteoporosis: a nationwide population-based cohort study.
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Efficacy and Safety of Celecoxib Combined With Jintiange Capsules for the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Medical science monitor : international medical journal of experimental and clinical research · 2026Trial
- Experimental study on the effect of warm acupuncture on the healing of bone nonunion in rats.Journal of the Chinese Medical Association : JCMA · 2026Article
- Toxicokinetics of a Single Oral Dose of Aflatoxin BToxins · 2025Article
- Effects of traditional Chinese medicine Zuo-Gui-Wan on gut microbiota in an osteoporotic mouse model.Journal of orthopaedic surgery and research · 2025Article
- Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.Frontiers in endocrinology · 2025Article
- Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation.BMC complementary medicine and therapies · 2024Article
- Manual Reduction and Plaster External Fixation for the Treatment of Closed Total Talus Dislocation: Case Report and Literature Review.Orthopaedic surgery · 2023Review
- Deciphering the protective effect of Buzhong Yiqi Decoction on osteoporotic fracture through network pharmacology and experimental validation.Journal of orthopaedic surgery and research · 2023Article
- The effects of E'Jiao on body composition, bone marrow adiposity and skeletal redox status in ovariectomised rats.International journal of medical sciences · 2023Article
- Jintiange combined with alfacalcidol improves muscle strength and balance in primary osteoporosis: A randomized, double-blind, double-dummy, positive-controlled, multicenter clinical trial.Journal of orthopaedic translation · 2022Article
- Prevalence, knowledge, and perception about the use of herbal medicines jazan - Saudi Arabia.Journal of family medicine and primary care · 2021Article
- Quality assessment of traditional and conventional medicine clinical practice guidelines for osteoporosis.Medicine · 2021Article
- Network Pharmacology Integrated with Molecular Docking Explores the Mechanisms of Naringin against Osteoporotic Fracture by Regulating Oxidative Stress.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Network Pharmacological Study ofBioMed research international · 2021Article
- Constitutions of Deficiency and Stasis of Traditional Chinese Medicine and Related Factors among Middle-Aged Women in Taiwan.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Research Progress of Male Reproductive Toxicity of Chinese Materia Medicas.Evidence-based complementary and alternative medicine : eCAM · 2019Review
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4 authors.
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Abstract
backgroundThere are no published studies regarding the efficacy of traditional Chinese medicine (TCM) for the prevention of osteoporotic fracture. Therefore, we conducted this nationwide, population-based cohort study to investigate the probable effect of TCM to decrease the fracture rate.
methodsWe identified cases with osteoporosis and selected a comparison group that was frequency-matched according to sex, age (per 5 years), diagnosis year of osteoporosis, and index year. The difference between the two groups in the development of fracture was estimated using the Kaplan-Meier method and the log-rank test.
resultsAfter inserting age, gender, urbanization level, and comorbidities into the Cox's proportional hazard model, patients who used TCM had a lower hazard ratio (HR) of fracture (adjusted HR: 0.47, 95% CI: 0.37-0.59) compared to the non-TCM user group. The Kaplan-Meier curves showed that osteoporosis patients who used TCM had a lower incidence of fracture events than those who did not (p < 0.00001). Our study also demonstrated that the longer the TCM use, the lesser the fracture rate.
conclusionOur study showed that TCM might have a positive impact on the prevention of osteoporotic fracture.
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