Evidence map›Paper›PMID 30717684›Full record

Trial reportBMC gastroenterology2019

Endoscopic injection sclerotherapy versus N-Butyl-2 Cyanoacrylate injection in the management of actively bleeding esophageal varices: a randomized controlled trial.

Mohamed A Elsebaey, Mohamed A Tawfik, Sherif Ezzat, Amal Selim, Heba Elashry, Sherief Abd-Elsalam

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03388125 (Endoscopic Injection Sclerotherapy Versus N-butyl-2-cyanoacrylate Injection in the Management of Actively Bleeding Esophageal Varices), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03388125 phase3unknown statusnot on this map

Endoscopic Injection Sclerotherapy Versus N-butyl-2-cyanoacrylate Injection in the Management of Actively Bleeding Esophageal Varices

TypeinterventionalSponsorSherief Abd-ElsalamRan2016 to 2022Enrolled113ConditionsBleeding Esophageal VaricesArmsInjection Sclerotherapy, N-butyl-2-cyanoacrylate
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Variceal Bleeding: Beyond Banding.Digestive diseases and sciences · 2022
    Review
  13. Early Identification of High-Risk Factors for Upper Gastrointestinal Bleeding.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  14. Observational
  15. Article
  16. Review
  17. Article
  18. Article
  19. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed A ElsebaeyInternal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Mohamed A TawfikInternal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt. m_atawfik@hotmail.com.ORCID http://orcid.org/0000-0002-8200-0535
Sherif EzzatInternal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Amal SelimInternal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Heba ElashryTropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Sherief Abd-ElsalamTropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may necessitate an alternative therapy for this group of patients. This study was conducted to assess the safety and efficacy of sclerotherapy versus cyanoacrylate injection for management of actively bleeding esophageal varices in cirrhotic patients.

methodsThis prospective study included 113 cirrhotic patients with actively bleeding esophageal varices. They were randomly treated by endoscopic sclerotherapy or cyanoacrylate injection as banding was not suitable for those patients due to profuse bleeding making unclear endoscopic visual field. Primary outcome was incidence of active bleeding control and secondary outcomes were incidence of six weeks rebleeding, complications, and mortality among the studied patients.

resultsInitial bleeding control was significantly higher in cyanoacrylate versus sclerotherapy groups (98.25, 83.93% respectively, P = 0.007). No significant differences between sclerotherapy and cyanoacrylate groups regarding rebleeding (26.79, 19.30% respectively, P = 0.344), complications, hospital stay or mortality rate were observed.

conclusionsBased on this single-center prospective study, both of these therapies appear to have relatively favorable outcomes, although cyanoacrylate injection may be superior to sclerotherapy for initial control of active bleeding.

trial registration[ClinicalTrials.gov Identifier: NCT03388125 ]-Date of registration: January 2, 2018 "Retrospectively registered".

Indexed as

Hemostatic TechniquesAdultAgedAged, 80 and overEnbucrilateEndoscopy, GastrointestinalEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHumansLiver CirrhosisMaleMiddle AgedProspective StudiesRecurrenceSclerosing SolutionsEnbucrilateSclerosing SolutionsCyanoacrylate injectionEsophageal varicesiInjection sclerotherapy

Identifiers

PMID30717684
PMCPMC6362581

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.