ArticleCancers2019
A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness.
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In one paragraph
Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
–field-weighted citation impact
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Who cites it
19 citing papers in PubMed.
- Regulating the dormancy of cancer stem cells: a novel approach to preventing cancer relapse.Cell death & disease · 2026Review
- GPNMB marks a quiescent cell population in melanoma and promotes metastasis formation.EMBO reports · 2025Article
- Correlation between iron accumulation and sarcopenia in middle-aged and elderly populations.BMC musculoskeletal disorders · 2025Article
- Bafilomycin A1 induces colon cancer cell death through impairment of the endolysosome system dependent on iron.Scientific reports · 2025Article
- Cancer stem cells: advances in knowledge and implications for cancer therapy.Signal transduction and targeted therapy · 2024Review
- Iron metabolism: backfire of cancer cell stemness and therapeutic modalities.Cancer cell international · 2024Review
- Association between serum iron levels and atherosclerotic cardiovascular diseases among American older adults: a cross-sectional study based on the National Health and Nutrition Examination Survey, 2009-2018.Frontiers in nutrition · 2024Article
- Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures.International journal of molecular sciences · 2023Article
- Targeting iron to contrast cancer progression.Current opinion in chemical biology · 2023Review
- Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators.Cancers · 2023Article
- Effects of iron modulation on mesenchymal stem cell-induced drug resistance in estrogen receptor-positive breast cancer.Oncogene · 2022Article
- Novel iron chelator SK4 demonstrates cytotoxicity in a range of tumour derived cell lines.Frontiers in molecular biosciences · 2022Article
- Association Between Serum Iron Status and Muscle Mass in Adults: Results From NHANES 2015-2018.Frontiers in nutrition · 2022Article
- The Impact of Iron Chelators on the Biology of Cancer Stem Cells.International journal of molecular sciences · 2021Review
- Reversing oncogenic transformation with iron chelation.Oncotarget · 2021Review
- Iron and Cancer: 2020 Vision.Cancer research · 2020Review
- Article
- Iron overload inhibits self-renewal of human pluripotent stem cells via DNA damage and generation of reactive oxygen species.FEBS open bio · 2020Article
- Article
Corrections and comments
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Authors and funding
19 authors.
Yuki KatsuraDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). kyuki82@yahoo.co.jp.
Toshiaki OharaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). t_ohara@cc.okayama-u.ac.jp.ORCID 0000-0003-1557-1589
Kazuhiro NomaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). knoma@md.okayama-u.ac.jp.
Takayuki NinomiyaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). nino_chan@msn.com.
Hajime KashimaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). hkashima@s.okayama-u.ac.jp.
Takuya KatoDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). alternative_winter_0203@yahoo.co.jp.
Hiroaki SatoDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). hiromaiaoi@gmail.com.
Satoshi KomotoDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). CometHeart13@gmail.com.
Toru NarusakaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). narusakat@gmail.com.
Yasuko TomonoShigei Medical Research Institute, Okayama 701-0202, Japan. yatomono@mx3.tiki.ne.jp.
Boyi XingDepartment of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. xingboyi1991@gmail.com.
Yuehua ChenDepartment of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. CynthiaChen9408@gmail.com.
Hiroshi TazawaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). htazawa@md.okayama-u.ac.jp.ORCID 0000-0003-4658-1050
Shunsuke KagawaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). skagawa@md.okayama-u.ac.jp.ORCID 0000-0002-3610-8211
Yasuhiro ShirakawaDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). yasuwr@md.okayama-u.ac.jp.
Tomonari KasaiSchool of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo 192-0914, Japan. kasaitnr@stf.teu.ac.jp.ORCID 0000-0002-9346-6664
Masaharu SenoLaboratory of Nano-Biotechnology, Okayama University Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama 700-8530, Japan. mseno@okayama-u.ac.jp.ORCID 0000-0001-8547-6259
Akihiro MatsukawaDepartment of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. amatsu@md.okayama-u.ac.jp.
Toshiyoshi FujiwaraDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan kyuki82@yahoo.co.jp (Y.K.). toshi_f@md.okayama-u.ac.jp.ORCID 0000-0002-5377-6051
Funding
Ministry of Health, Labour and Welfare 18K08539
Abstract
Excess iron causes cancer and is thought to be related to carcinogenesis and cancer progression including stemness, but the details remain unclear. Here, we hypothesized that stemness in cancer is related to iron metabolism and that regulating iron metabolism in cancer stem cells (CSCs) may be a novel therapy. In this study, we used murine induced pluripotent stem cells that expressed specific stem cell genes such as
Indexed as
cancer stem cellscombination therapyironstemness
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.