Evidence map›Paper›PMID 30717401›Full record

ReviewCells2019

Recent Insights into NCL Protein Function Using the Model Organism

Meagan D McLaren, Sabateeshan Mathavarajah, Robert J Huber

Abstract readReview
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Mfsd8 Modulates Growth and the Early Stages of Multicellular Development inFrontiers in cell and developmental biology · 2022
    Article
  5. Altered protein secretion in Batten disease.Disease models & mechanisms · 2021
    Review
  6. Review
  7. Role of LrrkA in the Control of Phagocytosis and Cell Motility inFrontiers in cell and developmental biology · 2021
    Article
  8. Review
  9. Aberrant Autophagy Impacts Growth and Multicellular Development in aFrontiers in cell and developmental biology · 2021
    Article
  10. Expanding the Neuroimaging Phenotype of Neuronal Ceroid Lipofuscinoses.AJNR. American journal of neuroradiology · 2020
    Article
  11. Cellular models of Batten disease.Biochimica et biophysica acta. Molecular basis of disease · 2020
    Review
  12. Article
  13. Review
  14. Calmodulin-mediated events during the life cycle of the amoebozoan Dictyostelium discoideum.Biological reviews of the Cambridge Philosophical Society · 2020
    Review
  15. Article
  16. Actin Waves and Dynamic Patterning of the Plasma Membrane.The Yale journal of biology and medicine · 2019
    Article
  17. Extracellular signaling in Dictyostelium.The International journal of developmental biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Meagan D McLarenDepartment of Biology, Trent University, 1600 West Bank Drive, Peterborough, ON K9L 0G2, Canada. meaganmclaren@trentu.ca.
Sabateeshan MathavarajahDepartment of Biology, Trent University, 1600 West Bank Drive, Peterborough, ON K9L 0G2, Canada. smathavarajah@trentu.ca.
Robert J HuberDepartment of Biology, Trent University, 1600 West Bank Drive, Peterborough, ON K9L 0G2, Canada. roberthuber@trentu.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuronal ceroid lipofuscinoses (NCLs) are a group of devastating neurological disorders that have a global distribution and affect people of all ages. Commonly known as Batten disease, this form of neurodegeneration is linked to mutations in 13 genetically distinct genes. The precise mechanisms underlying the disease are unknown, in large part due to our poor understanding of the functions of NCL proteins. The social amoeba

Indexed as

Models, BiologicalDictyosteliumHumansNeuronal Ceroid-LipofuscinosesOsmoregulationPhenotypeProtozoan ProteinsTripeptidyl-Peptidase 1Protozoan ProteinsTPP1 protein, humanTripeptidyl-Peptidase 1Batten diseaseCLN3CLN5developmentDictyostelium discoideumneuronal ceroid lipofuscinosisTPP1/CLN2

Identifiers

PMID30717401
PMCPMC6406579

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.