ArticleInternational journal of molecular sciences2019
Loliolide Presents Antiapoptosis and Antiscratching Effects in Human Keratinocytes.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
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- Loliolide: green monoterpenoid lactone with therapeutic and ecological significance-a comprehensive review with computational validation.Molecular diversity · 2026Review
- A comparative anti-proliferative and immunomodulatory analysis in wild and lab-acclimatized seaweed extracts unravel the functional biopotentials of Acrosiphonia orientalis.Scientific reports · 2026Article
- Regulation of apocarotenoids for quality improvement and biofortification of horticultural crops.Journal of advanced research · 2026Review
- Efficacy of Aster chinensis aerial parts metabolites in BALB/c mice model of Imiquimod-induced psoriasis skin inflammation.Inflammopharmacology · 2025Article
- GC-MS-employed Phytochemical Characterization and Anticancer, Antidiabetic, and Antioxidant Activity Screening of Lagerstroemia Thorelli.Chemistry & biodiversity · 2024Article
- IL-6 Inhibitory Compounds from the Aerial Parts ofMolecules (Basel, Switzerland) · 2024Article
- Influence of Nutrient Deprivation on the Antioxidant Capacity and Chemical Profile of Two Diatoms from GenusMarine drugs · 2024Article
- Exploring FourMolecules (Basel, Switzerland) · 2024Review
- Comprehensive overview of different medicinal parts fromFrontiers in pharmacology · 2024Review
- Loliolide inInternational journal of molecular sciences · 2023Article
- Wound Healing Effect of Supercritical Carbon DioxidePlants (Basel, Switzerland) · 2023Article
- Intra-Species Variations of Bioactive Compounds of Two Dictyota Species from the Adriatic Sea: Antioxidant, Antimicrobial, Dermatological, Dietary, and Neuroprotective Potential.Antioxidants (Basel, Switzerland) · 2023Article
- Enhanced Wound Healing Potential ofMarine drugs · 2023Article
- Phytochemical Analysis and Molecular Identification of Green MacroalgaeMolecules (Basel, Switzerland) · 2022Article
- Antioxidant Capacity ofPlants (Basel, Switzerland) · 2022Article
- A theoretical study to the loliolide molecule and its isomers: a study by circular dichroism, QTAIM, and NMR theoretical methods.Journal of molecular modeling · 2021Article
- Antioxidant and Anti-Inflammatory Effects of White Mulberry (Molecules (Basel, Switzerland) · 2021Article
- Anti-Hepatocellular Carcinoma (HepG2) Activities of Monoterpene Hydroxy Lactones Isolated from the Marine MicroalgaMarine drugs · 2020Article
- Comprehensive Metabolome Analysis of Fermented Aqueous Extracts ofMolecules (Basel, Switzerland) · 2020Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Loliolide is a monoterpenoid hydroxylactone present in freshwater algae that has anti-inflammatory and antiaging activity; however, its effects on ultraviolet-damaged skin have yet to be elucidated. This study investigated the antiapoptosis and wound-healing effects of loliolide using HaCaT cells (a human keratinocyte cell line). Loliolide inhibited the expression of reactive oxygen species (ROS) induced by ultraviolet radiation as well as wrinkle formation-related matrix metalloproteinase genes and increased the expression of the damage repair-related gene SIRT1. The apoptosis signaling pathway was confirmed by Western blot analysis, which showed that loliolide was able to reduce the expression of caspases 3, 8, and 9, which are related to ROS-induced apoptosis. In addition, Western blotting, reverse-transcription polymerase chain reaction (PCR), and real-time PCR analyses showed that loliolide enhanced the expression of the epidermal growth factor receptor signaling pathway (PI3K, AKT) and migration factors, such as K6, K16, and K17; keratinocyte growth factor; and inflammatory cytokines, such as interleukin (IL)-1, IL-17, and IL-22 expressed during the cellular scratching process, suggesting a putative wound-healing ability. Because of the antiapoptosis and antiscratching effects on skin of both loliolide and loliolide-rich
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.