Evidence map›Paper›PMID 30717366›Full record

ArticleMarine drugs2019

Neorogioltriol and Related Diterpenes from the Red Alga

Maria G Daskalaki, Dimitra Vyrla, Maria Harizani, Christina Doxaki, Aristides G Eliopoulos, Vassilios Roussis, Efstathia Ioannou, Christos Tsatsanis, Sotirios C Kampranis

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Diet supplementation with the macroalgaeFrontiers in nutrition · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. The Ocean's Pharmacy: Health Discoveries in Marine Algae.Molecules (Basel, Switzerland) · 2024
    Review
  11. Review
  12. Review
  13. Marine drugs · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Maria G DaskalakiLaboratory of Biochemistry, School of Medicine, University of Crete, Heraklion 70013, Greece. m.daskalaki@med.uoc.gr.ORCID 0000-0002-4424-2779
Dimitra VyrlaInstitute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete 71110, Greece. di_micro@hotmail.com.
Maria HarizaniSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece. mariachariz@pharm.uoa.gr.
Christina DoxakiLaboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 70013, Greece. cdoxaki@med.uoc.gr.
Aristides G EliopoulosInstitute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete 71110, Greece. eliopag@med.uoa.gr.
Vassilios RoussisSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece. roussis@pharm.uoa.gr.
Efstathia IoannouSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece. eioannou@pharm.uoa.gr.
Christos TsatsanisLaboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 70013, Greece. tsatsani@uoc.gr.ORCID 0000-0003-1214-4151
Sotirios C KampranisLaboratory of Biochemistry, School of Medicine, University of Crete, Heraklion 70013, Greece. soka@plen.ku.dk.ORCID 0000-0001-6208-1684
National and Kapodistrian University of Athens · GRUniversity of Crete · GRFORTH Institute of Molecular Biology and Biotechnology · GRUniversity of Copenhagen · DK

Funding

General Secretariat for Research and Technology MIS 5002670General Secretariat for Research and Technology Τ1ΕΔΚ-04048
6 · The paper itself

Abstract

Macrophages are central mediators of inflammation, orchestrating the inflammatory response through the production of cytokines and nitric oxide. Macrophages obtain pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes, which can be modulated by soluble factors, including natural products. Despite the crucial protective role of inflammation, chronic or deregulated inflammation can lead to pathological states, such as autoimmune diseases, metabolic disorders, cardiovascular diseases, and cancer. In this case, we studied the anti-inflammatory activity of neorogioltriol (

Indexed as

AnimalsCell ProliferationDextran SulfateDiterpenesInflammatory Bowel DiseasesLaurenciaMacrophagesMiceMice, Inbred C57BLMolecular StructureRAW 264.7 CellsDextran SulfateDiterpenesneorogioltriolcolitiscytokinehalogenated diterpenesLaurencianeorogioltriolnitric oxideTNF-alpha

Identifiers

PMID30717366
PMCPMC6410277
OpenAlexW2912084655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.