ArticlePharmacy (Basel, Switzerland)2019
Complexity of Medicine Regimens and Patient Perception of Medicine Burden.
Article in Pharmacy (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Effects of a pharmaceutical care intervention on clinical outcomes and patient adherence in coronary heart disease: the MIMeRiC randomized controlled trial.BMC cardiovascular disorders · 2021Trial
- Association of polypharmacy and medication class diversity with postoperative complications following operative ankle fracture repair.Proceedings (Baylor University. Medical Center) · 2026Article
- Medicine at work: a qualitative study into patients' experiences with medication self-management and burden in the context of work.Journal of occupational health · 2026Article
- Medication regimen complexity in cancer patients: an overlooked issue for healthcare team.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Exploring Factors Associated with Health Status and Dietary Supplement Use Among Portuguese Adults: A Cross-Sectional Online Survey.Healthcare (Basel, Switzerland) · 2025Article
- Experience of the Burden of Using Multiple Medicines and the Associated Impact on Health-Related Quality of Life.Journal of patient experience · 2025Article
- Prevalence and influencing factors of medication-related burden among patients with late-life depression in typical city of eastern China: a cross-sectional study.BMC public health · 2024Article
- The Arabic medication-related burden quality of life (MRB-QoL) tool: Cross-cultural adaptation and content validation.Exploratory research in clinical and social pharmacy · 2024Article
- Complexity of the Therapeutic Regimen in Older Adults with Cancer: Associated Factors.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Evaluation of viral suppression and medication-related burden among HIV-infected adults in a secondary care facility.Exploratory research in clinical and social pharmacy · 2024Article
- Effect of Multi-Dose Dispensing on Medication Regimen Complexity: A Real-World Study.Journal of clinical medicine · 2024Article
- Medication-related burden and its association with medication adherence among elderly tuberculosis patients in Guizhou, China: a cross-sectional study.Frontiers in pharmacology · 2024Article
- Evaluating the Medication Regimen Complexity Score as a Predictor of Clinical Outcomes in the Critically Ill.Journal of clinical medicine · 2022Article
- Polypharmacy, Medication-Related Burden and Antiretroviral Therapy Adherence in People Living with HIV Aged 50 and Above: A Cross-Sectional Study in Hunan, China.Patient preference and adherence · 2022Article
- Medication-related burden and associated factors among diabetes mellitus patients at Felege Hiwot Comprehensive Specialized Hospital in northwest Ethiopia.Frontiers in clinical diabetes and healthcare · 2022Article
- Article
- Exploring polypharmacy burden among elderly patients with chronic diseases in Chinese community: a cross-sectional study.BMC geriatrics · 2021Article
- Impact of Medication Regimen Simplification on Medication Administration Times and Health Outcomes in Residential Aged Care: 12 Month Follow Up of the SIMPLER Randomized Controlled Trial.Journal of clinical medicine · 2020Article
- Cross-Cultural Adaptation and Reliability Testing of Chinese Version of the Living with Medicines Questionnaire in Elderly Patients with Chronic Diseases.Patient preference and adherence · 2020Article
- Medication-Related Burden and Medication Adherence Among Geriatric Patients in Kuwait: A Cross-Sectional Study.Frontiers in pharmacology · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
From the patient perspective, medicine burden is more than the number of medicines, or the complexity of medicine regimens they need to manage. Relationships between the number of medicines, regimen complexity and patient perception of medicine burden are under-researched. This cross-sectional study measured regimen complexity and determined how this and patient perceived burden are affected by the therapeutic group. Regimen complexity was measured in patients presenting prescriptions to six community pharmacies in South-East England. A sub-sample (166) also completed the Living with Medicines Questionnaire which measures patient perceived burden. The 492 patients were prescribed 2700 medicines (range 1 to 23). Almost half used at least one non-oral formulation. Complexity was correlated strongly with the number of medicines (r = 0.94), number of therapeutic groups (r = 0.84) and number of formulations (r = 0.73). Patients using medicines for skin, eye and respiratory conditions had the highest complexity scores. Increasing the number of medicines, frequency of dosing, number of non-oral formulations and number of different therapeutic groups all increased medicine burden. Although cardiovascular medicines were the most common medicines used by the majority of patients (60%), those for neurological, psychiatric and gastro-intestinal conditions were most strongly associated with high burden. Studies are required to determine medicine burden in different conditions, especially neurological conditions, including chronic pain.
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