Evidence map›Paper›PMID 30717307›Full record

ReviewCancers2019

Integrating Small Animal Irradiators withFunctional Imaging for Advanced Preclinical Radiotherapy Research.

Mihaela Ghita, Kathryn H Brown, Olivia J Kelada, Edward E Graves, Karl T Butterworth

Abstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Combination Image-Guided and Antibody-Targeted α-Therapy Before Targeted Immunotherapy for Treatment of Solid Tumors.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Irradiation immunity interactions.Journal of medical imaging and radiation oncology · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mihaela GhitaCentre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7AE, Northern Ireland, UK. m.ghita@qub.ac.uk.
Kathryn H BrownCentre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7AE, Northern Ireland, UK. kbrown40@qub.ac.uk.
Olivia J KeladaMolecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1088, USA. olivia.kelada@nih.gov.
Edward E GravesDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305-5152, USA. egraves@stanford.edu.
Karl T ButterworthCentre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast BT9 7AE, Northern Ireland, UK. k.butterworth@qub.ac.uk.

Funding

National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/R001553/1
6 · The paper itself

Abstract

Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects of the clinical scenario in radiation oncology is critical to translational success. The use of small animal irradiators with disease relevant mouse models and advanced in vivo imaging approaches offers unique possibilities to interrogate the radiotherapy response of tumors and normal tissues with high potential to translate to improvements in clinical outcomes. The present review highlights the current technology and applications of small animal irradiators, and explores how these can be combined with molecular and functional imaging in advanced preclinical radiotherapy research.

Indexed as

functional imagingpreclinical radiotherapyradiation oncologyradiobiologysmall animal irradiators

Identifiers

PMID30717307
PMCPMC6406472

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.