Evidence map›Paper›PMID 30717179›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects.

Solida Long, Diana I S P Resende, Anake Kijjoa, Artur M S Silva, Ricardo Fernandes, Cristina P R Xavier, M Helena Vasconcelos, Emília Sousa, Madalena M M Pinto

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Anti-Inflammatory Evaluation of Pyrazino[2,1-Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Effect of Indole-Containing Pyrazino[2,1-Antibiotics (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Article
  7. Indole-Containing Pyrazino[2,1-ACS medicinal chemistry letters · 2022
    Article
  8. Article
  9. Article
  10. Synthesis of Novel Methyl 3-(hetero)arylthieno[3,2-Molecules (Basel, Switzerland) · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Solida LongLaboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. up201502099@ff.up.pt.ORCID 0000-0002-3142-4864
Diana I S P ResendeLaboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. dresende@ff.up.pt.ORCID 0000-0002-4077-6060
Anake KijjoaInterdisciplinary Centre of Marine and Environmental Research (CIIMAR), 4450-208 Matosinhos, Portugal. ankijjoa@icbas.up.pt.ORCID 0000-0002-3321-1061
Artur M S SilvaOrganic Chemistry and Natural Products Unit (QOPNA), Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. artur.silva@ua.pt.ORCID 0000-0003-2861-8286
Ricardo FernandesInstituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal. ricardojorgefernandes@gmail.com.ORCID 0000-0003-0301-7257
Cristina P R XavierInstituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal. cristinax@ipatimup.pt.ORCID 0000-0002-4613-1917
M Helena VasconcelosInstituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal. hvasconcelos@ipatimup.pt.ORCID 0000-0002-7801-4643
Emília SousaLaboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. esousa@ff.up.pt.ORCID 0000-0002-5397-4672
Madalena M M PintoLaboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madalena@ff.up.pt.ORCID 0000-0002-4676-1409

Funding

European Regional Development Fund POCI-01-0145-FEDER-028736, POCI-01-0145-FEDER-016790, UID/Multi/04423/2013
6 · The paper itself

Abstract

New quinazolinone derivatives of the marine-derived alkaloids fiscalin B (

Indexed as

AlkaloidsAntineoplastic AgentsCell Line, TumorEpithelial CellsHumansInhibitory Concentration 50Molecular StructureNeuronsNeuroprotective AgentsPeptidomimeticsQuinazolinonesStructure-Activity RelationshipAlkaloidsAntineoplastic AgentsNeuroprotective AgentsPeptidomimeticsQuinazolinonesantitumorenantioselectivityfiscalin Bfumiquinazolineneuroprotectionquinazolinones

Identifiers

PMID30717179
PMCPMC6384550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.