Evidence map›Paper›PMID 30717171›Full record

ArticleMaterials (Basel, Switzerland)2019

Study of Two Bovine Bone Blocks (Sintered and Non-Sintered) Used for Bone Grafts: Physico-Chemical Characterization and In Vitro Bioactivity and Cellular Analysis.

Sergio Alexandre Gehrke, Patricia Mazón, Leticia Pérez-Díaz, José Luis Calvo-Guirado, Pablo Velásquez, Juan Manuel Aragoneses, Manuel Fernández-Domínguez, Piedad N De Aza

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sergio Alexandre GehrkeDepartment of Research, Biotecnos, Cuareim 1483, CP 11100 Montevideo, Uruguay. sergio.gehrke@hotmail.com.ORCID 0000-0002-5863-9101
Patricia MazónDepartment of Materiales, Óptica y Tecnología Electrónica, Universidad Miguel Hernández, Avda, Universidad s/n, 03202 Elche (Alicante), Spain. pmazon@umh.es.ORCID 0000-0001-7704-7577
Leticia Pérez-DíazLaboratorio de Interacciones Molecular, Facultad de Ciencias, Universidad de la Republica, Calle Iguá 4225, 11400 Montevideo, Uruguay. letperez@gmail.com.
José Luis Calvo-GuiradoDepartment of Oral and Implant Surgery, Faculty of Health Sciences, Universidad Católica de Murcia (UCAM), 30107 Murcia, Spain. jlcalvo@ucam.edu.ORCID 0000-0002-4067-2253
Pablo VelásquezInstituto de Bioingenieria, Universidad Miguel Hernández, Avda, Ferrocarril s/n, 03202 Elche (Alicante), Spain. pavelasquez@umh.es.ORCID 0000-0002-5142-4992
Juan Manuel AragonesesDepartment of Dental Research in Universidad Federico Henriquez y Carvajal (UFHEC), Santo Domingo 10107, Dominican Republic. jaragoneses@ufhec.edu.do.
Manuel Fernández-DomínguezDepartment of Translational Medicine, CEU San Pablo University, 28223 Madrid, Spain. clinferfun@yahoo.es.
Piedad N De AzaInstituto de Bioingenieria, Universidad Miguel Hernández, Avda, Ferrocarril s/n, 03202 Elche (Alicante), Spain. piedad@umh.es.ORCID 0000-0001-9316-4407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, the physicochemical properties and in vitro bioactivity and cellular viability of two commercially available bovine bone blocks (allografts materials) with different fabrication processes (sintered and not) used for bone reconstruction were evaluated in order to study the effect of the microstructure in the in vitro behavior. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, mechanical resistance of blocks, mercury porosimetry analysis, in vitro bioactivity, and cell viability and proliferation were performed to compare the characteristics of both allograft materials against a synthetic calcium phosphate block used as a negative control. The herein presented results revealed a very dense structure of the low-porosity bovine bone blocks, which conferred the materials' high resistance. Moreover, relatively low gas, fluid intrusion, and cell adhesion were observed in both the tested materials. The structural characteristics and physicochemical properties of both ceramic blocks (sintered and not) were similar. Finally, the bioactivity, biodegradability, and also the viability and proliferation of the cells was directly related to the physicochemical properties of the scaffolds.

Indexed as

biomaterialsbone graftbovine bonecellular analysisceramic blocks

Identifiers

PMID30717171
PMCPMC6384848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.