Evidence map›Paper›PMID 30717161›Full record

ArticleNanomaterials (Basel, Switzerland)2019

Electrospun Filaments Embedding Bioactive Glass Particles with Ion Release and Enhanced Mineralization.

Francesca Serio, Marta Miola, Enrica Vernè, Dario Pisignano, Aldo R Boccaccini, Liliana Liverani

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Francesca SerioDipartimento di Matematica e Fisica "Ennio De Giorgi," Università del Salento, Via Arnesano, I-73100 Lecce, Italy. francescaserio@unisalento.it.
Marta MiolaApplied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, I-10129 Torino, Italy. marta.miola@polito.it.
Enrica VernèApplied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, I-10129 Torino, Italy. enrica.verne@polito.it.
Dario PisignanoDipartimento di Fisica, Università di Pisa, Largo B. Pontecorvo 3, I-56127 Pisa, Italy. dario.pisignano@unipi.it.ORCID 0000-0003-3758-5199
Aldo R BoccacciniInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, D-91058 Erlangen, Germany. aldo.boccaccini@fau.de.ORCID 0000-0002-7377-2955
Liliana LiveraniInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, D-91058 Erlangen, Germany. liliana.liverani@fau.de.ORCID 0000-0002-4270-4861
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEPolitecnico di Torino · ITUniversity of Pisa · ITUniversity of Salento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efforts in tissue engineering aim at creating scaffolds that mimic the physiological environment with its structural, topographical and mechanical properties for restoring the function of damaged tissue. In this study we introduce composite fibres made by a biodegradable poly(lactic acid) (PLLA) matrix embedding bioactive silica-based glass particles (SBA2). Electrospinning is performed to achieve porous PLLA filaments with uniform dispersion of bioactive glass powder. The obtained composite fibres show in aligned arrays significantly increased elastic modulus compared with that of neat polymer fibres during uniaxial tensile stress. Additionally, the SBA2 bioactivity is preserved upon encapsulation as highlighted by the promoted deposition of hydroxycarbonate apatite (HCA) upon immersion in simulated body fluid solutions. HCA formation is sequential to earlier processes of polymer erosion and ion release leading to acidification of the surrounding solution environment. These findings suggest PLLA-SBA2 fibres as a composite, multifunctional system which might be appealing for both bone and soft tissue engineering applications.

Indexed as

bioactive glasscomposite fibreselectrospinningpoly(lactic acid) (PLLA)scaffolds

Identifiers

PMID30717161
PMCPMC6410207
OpenAlexW2911530549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.