Evidence map›Paper›PMID 30717153›Full record

Trial reportNutrients2019

Efficacy and Safety of

Yun-Ha Hwang, Shinwon Park, Jong-Woo Paik, Soo-Wan Chae, Dong-Hyun Kim, Doc-Gyun Jeong, Eunji Ha, Myeongju Kim, Gahae Hong, Soo-Hyun Park and 5 more

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 129 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 18 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05194033 nacompletednot on this mapstarted 2022, after this paper: background citation

Efficacy and Safety of Oral Lactobacillus Plantarum GUANKE (CGMCC NO.21720) in Enhancement of Antibody Level After SARS-CoV-2 Vaccination: A Prospective, Randomized, Double-blind, Placebo-Controlled Trial (Trial 1)

TypeinterventionalSponsorPeking UniversityRan2022 to 2022Enrolled31ConditionsSARS-CoV-2ArmsProbiotics daily, Placebo daily
NCT05195047 nacompletednot on this mapstarted 2022, after this paper: background citation

Efficacy and Safety of Oral Lactobacillus Plantarum GUANKE (CGMCC NO.21720) in Enhancement of Antibody Level After SARS-CoV-2 Vaccination: A Prospective, Randomized, Double-blind, Placebo-Controlled Trial (Trial 2)

TypeinterventionalSponsorPeking UniversityRan2022 to 2022Enrolled44ConditionsSARS-CoV-2Arms1 week placebo(Week 1), 1 week of probiotics(Week 1), 1 week placebo(Week 2), 1 week of probiotics(Week 2), 1 week placebo(Week 3)
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 18 syntheses or guidelines pooled it, 237 citations in OpenAlex.

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  7. The effects ofFrontiers in nutrition · 2025
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  19. Efficacy and Safety ofNutrients · 2025
    Trial
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Yun-Ha HwangDONGWHA Pharm Research Institute, 35-71, Topsil-ro, Giheung-gu, Yongin-si 17084, Korea. yunha.hwang@dong-wha.co.kr.
Shinwon ParkEwha Brain Institute and Department of Brain & Cognitive Sciences, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea. shinwon.s.park@gmail.com.
Jong-Woo PaikDepartment of Psychiatry, College of Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. paikjw@khu.ac.kr.
Soo-Wan ChaeClinical Trial Center for Functional Foods, Chonbuk National University Hospital, 20, Geonjiro Deokjin-gu, Jeonju-si 54907, Korea. swchae@jbctc.org.
Dong-Hyun KimDepartment of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. dhkim@khu.ac.kr.
Doc-Gyun JeongDONGWHA Pharm Research Institute, 35-71, Topsil-ro, Giheung-gu, Yongin-si 17084, Korea. docgyun.jeong@dong-wha.co.kr.
Eunji HaEwha Brain Institute and Department of Brain & Cognitive Sciences, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea. eunji.i.ha@gmail.com.
Myeongju KimEwha Brain Institute and Department of Brain & Cognitive Sciences, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea. myeongju.j.kim@gmail.com.ORCID 0000-0003-0543-3019
Gahae HongEwha Brain Institute and Department of Brain & Cognitive Sciences, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea. gahae.h.hong@ewha.ac.kr.
Soo-Hyun ParkClinical Trial Center for Functional Foods, Chonbuk National University Hospital, 20, Geonjiro Deokjin-gu, Jeonju-si 54907, Korea. shpark@jbctc.org.ORCID 0000-0002-7419-5221
Su-Jin JungClinical Trial Center for Functional Foods, Chonbuk National University Hospital, 20, Geonjiro Deokjin-gu, Jeonju-si 54907, Korea. sjjeong@jbctc.org.
Sang-Min LeeDepartment of Psychiatry, College of Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. maumdoctor@gmail.com.
Kyu-Heum NaDONGWHA Pharm Research Institute, 35-71, Topsil-ro, Giheung-gu, Yongin-si 17084, Korea. kyuheum.na@dong-wha.co.kr.
Jungyoon KimEwha Brain Institute and Department of Brain & Cognitive Sciences, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea. jungyoon.kimm@ewha.ac.kr.
Young-Chul ChungResearch Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, 20, Geonjiro Deokjin-gu, Jeonju-si 54907, Korea. chungyc@jbnu.ac.kr.
Ewha Womans University · KRDongwha Pharm (South Korea) · KRJeonbuk National University Hospital · KRKyung Hee University · KR

Funding

Korea Health Industry Development Institute HI15C0997the National Fire Agency MPSS-Fire Fighting Safety-2016-86
6 · The paper itself

Abstract

Early intervention using dietary supplements may be effective in alleviating cognitive impairment among individuals with mild cognitive impairment (MCI). This study investigated the efficacy and safety of

Indexed as

Lactiplantibacillus plantarumSoy FoodsAgedBrain-Derived Neurotrophic FactorCognitive DysfunctionDouble-Blind MethodFecesFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedProbioticsTreatment OutcomeBrain-Derived Neurotrophic FactorBrain-derived neurotrophic factorCognitive impairmentLactobacillus plantarum C29-fermented soybean (DW2009)Mild cognitive impairment

Identifiers

PMID30717153
PMCPMC6412773
OpenAlexW2914115244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.