Evidence map›Paper›PMID 30716700›Full record

ArticleiScience2019

Viral Infection or IFN-α Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels.

William M McDougall, Jill M Perreira, Hui-Fang Hung, Anastassiia Vertii, E Xiaofei, Wendy Zimmerman, Timothy F Kowalik, Stephen Doxsey, Abraham L Brass

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

William M McDougallDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Jill M PerreiraDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Hui-Fang HungCell Biology Section, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda, Bethesda, MD 20814, USA.
Anastassiia VertiiDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
E XiaofeiDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Wendy ZimmermanProgram in Molecular Medicine University of Massachusetts Medical School, Worcester, MA 01605, USA.
Timothy F KowalikDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Stephen DoxseyProgram in Molecular Medicine University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: stephen.doxsey@umassmed.edu.
Abraham L BrassDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA; Gastroenterology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; Peak Gastroenterology Associates, Colorado Springs, CO 80907, USA. Electronic address: abraham.brass@umassmed.edu.
University of Massachusetts Chan Medical School · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital microcephaly occurs in utero during Zika virus (ZIKV) infection. The single-gene disorder, Majewski osteodysplastic primordial dwarfism type II (MOPDII), also leads to microcephaly and is concomitant with a decrease in the centrosomal protein, pericentrin (PCNT). This protein is a known contributor of mitotic spindle misorientation and ultimately, microcephaly. Similar to MOPDII, either viral infection or interferon (IFN)-α exposure reduced PCNT levels at the mitotic spindle poles. We unexpectedly found that infection of cells with any one of a diverse set of viruses, such as ZIKV, dengue virus, cytomegalovirus, influenza A virus, or hepatitis B virus, or treatment of cells with the anti-viral cytokine, IFN-α, produced mitotic spindle misorientation. These findings demonstrate a related mechanism for the development of microcephaly in viral infection, the host's antiviral IFN response, and primordial dwarfism.

Indexed as

Biological SciencesCell BiologyPathophysiologyVirology

Identifiers

PMID30716700
PMCPMC6360249
OpenAlexW2911926701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.