ArticleNeurobiology of aging2019
Aged rats with preserved memory dynamically recruit hippocampal inhibition in a local/global cue mismatch environment.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Tuning excitatory input to fast-spiking parvalbumin-positive interneurons: a lever for plasticity and hyperexcitability across the lifespan.Frontiers in synaptic neuroscience · 2026Article
- Altered NPTX2 dynamics associated with impaired cognitive aging.bioRxiv : the preprint server for biology · 2025Article
- Proteins with cognition-associated structural changes in a rat model of aging exhibit reduced refolding capacity.Science advances · 2025Article
- Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions.Neurobiology of aging · 2025Article
- An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience.bioRxiv : the preprint server for biology · 2024Article
- Object-place-context learning impairment correlates with spatial learning impairment in aged Long-Evans rats.Hippocampus · 2024Article
- Retrosplenial cortex microglia and perineuronal net densities are associated with memory impairment in aged rhesus macaques.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Individual differences in age-related neurocognitive outcomes: within-subject assessment of memory for odors.Frontiers in aging neuroscience · 2023Article
- Loss of functional heterogeneity along the CA3 transverse axis in aging.Current biology : CB · 2022Article
- Article
- Decreased investigatory head scanning during exploration in learning-impaired, aged rats.Neurobiology of aging · 2021Article
- Heterogeneity of Age-Related Neural Hyperactivity along the CA3 Transverse Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Significance of inhibitory recruitment in aging with preserved cognition: limiting gamma-aminobutyric acid type A α5 function produces memory impairment.Neurobiology of aging · 2020Article
- Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via CA1-Frontal Circuit.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- What are the threats to successful brain and cognitive aging?Neurobiology of aging · 2019Article
- Reduced cognitive performance in aged rats correlates with increased excitation/inhibition ratio in the dentate gyrus in response to lateral entorhinal input.Neurobiology of aging · 2019Article
- Aged rats with intact memory show distinctive recruitment in cortical regions relative to young adults in a cue mismatch task.Behavioral neuroscience · 2019Article
- Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction.International review of neurobiology · 2019Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Similar to elderly humans, aged outbred Long-Evans rats exhibit individual differences in memory abilities, including a subset of aged rats that maintain memory function on par with young adults. Such individuals provide a basis for investigating mechanisms of resilience to age-related decline. The present study examined hippocampal gene expression in young adults and aged rats with preserved memory function under behavioral task conditions well established for assessing information processing central to the formation of episodic memory. Although behavioral measures and hippocampal gene induction associated with neural activity and synaptic plasticity were similar across age groups, a marker for inhibitory interneuron function in the hippocampal formation was distinctively increased only in aged rats but not in young adults. Because heightened hippocampal neural activity is associated with age-related memory impairment across species, including rats, monkeys, and humans, this finding may represent an adaptive homeostatic adjustment necessary to maintain neural plasticity and memory function in aging.
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