Evidence map›Paper›PMID 30716459›Full record

ArticleNeuroImage2019

Cross-scanner and cross-protocol diffusion MRI data harmonisation: A benchmark database and evaluation of algorithms.

Chantal Mw Tax, Francesco Grussu, Enrico Kaden, Lipeng Ning, Umesh Rudrapatna, C John Evans, Samuel St-Jean, Alexander Leemans, Simon Koppers, Dorit Merhof and 9 more

Abstract read
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

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  15. DDEvENet: Evidence-based ensemble learning for uncertainty-aware brain parcellation using diffusion MRI.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2025
    Article
  16. Article
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  18. Learning disentangled representations to harmonize connectome network measures.Journal of medical imaging (Bellingham, Wash.) · 2025
    Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chantal Mw TaxCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom. Electronic address: taxc@cardiff.ac.uk.
Francesco GrussuQueen Square MS Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom; Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom.
Enrico KadenCentre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom.
Lipeng NingHarvard Medical School, Boston, MA, United States.
Umesh RudrapatnaCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.
C John EvansCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.
Samuel St-JeanImage Sciences Institute, Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Alexander LeemansImage Sciences Institute, Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Simon KoppersDepartment of Radiology, University of Pennsylvania and the Children's Hospital of Philadelphia, Philadelphia, PA, United States; Institute of Imaging & Computer Vision, RWTH Aachen University, Aachen, Germany.
Dorit MerhofInstitute of Imaging & Computer Vision, RWTH Aachen University, Aachen, Germany.
Aurobrata GhoshCentre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom.
Ryutaro TannoCentre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom; Machine Intelligence and Perception Group, Microsoft Research Cambridge, Cambridge, United Kingdom.
Daniel C AlexanderCentre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom.
Stefano ZappalàCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.
Cyril CharronCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.
Slawomir KusmiaCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.
David Ej LindenCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.
Derek K JonesCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Jelle VeraartNew York University, New York, NY, United States; imec-Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium.

Funding

Multimodal brain-connectivity biomarkers for profiling heterogeneity in early psychosisR21MH116352 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI NING, LIPENG · 2018 to 2019
$492k
Personalized target selection for TMS therapy using functional vs. structural connectivity MRIR21MH115280 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI CAMPRODON, JOAN A, NING, LIPENG · 2018 to 2019
$443k
Medical Research Council MR/K004360/1NIMH NIH HHS R21 MH115280NIMH NIH HHS R21 MH116352Wellcome Trust
6 · The paper itself

Abstract

Diffusion MRI is being used increasingly in studies of the brain and other parts of the body for its ability to provide quantitative measures that are sensitive to changes in tissue microstructure. However, inter-scanner and inter-protocol differences are known to induce significant measurement variability, which in turn jeopardises the ability to obtain 'truly quantitative measures' and challenges the reliable combination of different datasets. Combining datasets from different scanners and/or acquired at different time points could dramatically increase the statistical power of clinical studies, and facilitate multi-centre research. Even though careful harmonisation of acquisition parameters can reduce variability, inter-protocol differences become almost inevitable with improvements in hardware and sequence design over time, even within a site. In this work, we present a benchmark diffusion MRI database of the same subjects acquired on three distinct scanners with different maximum gradient strength (40, 80, and 300 mT/m), and with 'standard' and 'state-of-the-art' protocols, where the latter have higher spatial and angular resolution. The dataset serves as a useful testbed for method development in cross-scanner/cross-protocol diffusion MRI harmonisation and quality enhancement. Using the database, we compare the performance of five different methods for estimating mappings between the scanners and protocols. The results show that cross-scanner harmonisation of single-shell diffusion data sets can reduce the variability between scanners, and highlight the promises and shortcomings of today's data harmonisation techniques.

Indexed as

AlgorithmsAdultBenchmarkingBrain MappingDatabases as TopicDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMaleYoung Adult

Identifiers

PMID30716459
PMCPMC6556555

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.