ArticleNeuroImage2019
The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Go with the (Blood) Flow: A Systematic Review on the Relationship Between Dynamic Functional Connectivity and Information Processing Speed.Neuropsychology review · 2026Pooled it
- Cognitive reserve in individuals with frontotemporal dementia: a systematic review.Journal of clinical and experimental neuropsychology · 2024Pooled it
- Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics, predictive value and implications for clinical trials.Brain imaging and behavior · 2022Pooled it
- The presymptomatic phase of amyotrophic lateral sclerosis: are we merely scratching the surface?Journal of neurology · 2021Pooled it
- The imaging signature of C9orf72 hexanucleotide repeat expansions: implications for clinical trials and therapy development.Brain imaging and behavior · 2021Pooled it
- Mirror therapy reduces excessive variability of motor network in stroke patients: a randomized controlled trial.European journal of physical and rehabilitation medicine · 2025Trial
- Mapping the multiscale neuroanatomy of GRN-related frontotemporal dementia using mode-based morphometry.NeuroImage. Clinical · 2026Article
- Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia.Brain communications · 2026Article
- Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers.Annals of clinical and translational neurology · 2025Article
- Static and Dynamic Dysconnectivity in Early Psychosis: Relationship With Symptom Dimensions.Schizophrenia bulletin · 2024Article
- The risk of cannabis use disorder is mediated by altered brain connectivity: A chronnectome study.Addiction biology · 2024Article
- Resting-state fMRI functional connectome of C9orf72 mutation status.Annals of clinical and translational neurology · 2024Article
- Changes in oscillatory patterns of microstate sequence in patients with first-episode psychosis.Scientific data · 2024Article
- Energy landscape analysis of brain network dynamics in Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers.Journal of neurology · 2023Article
- Frontotemporal lobar degeneration.Nature reviews. Disease primers · 2023Review
- Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Editorial: Insights into structural and functional organization of the brain: evidence from neuroimaging and non-invasive brain stimulation techniques.Frontiers in psychiatry · 2023Article
- Editorial: Case reports in neuroimaging and stimulation.Frontiers in psychiatry · 2023Article
- Functional connectivity in behavioral variant frontotemporal dementia.Brain and behavior · 2022Review
Corrections and comments
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Authors and funding
37 authors.
Funding
Abstract
Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 472 at-risk FTD subjects from the Genetic Frontotemporal dementia research Initiative (GENFI) cohort. We considered 249 subjects with FTD-related pathogenetic mutations and 223 mutation non-carriers (HC). Dynamic connectivity was evaluated using independent component analysis and sliding-time window correlation to rs-fMRI data, and meta-state measures of global brain flexibility were extracted. Results show that presymptomatic FTD exhibits diminished dynamic fluidity, visiting less meta-states, shifting less often across them, and travelling through a narrowed meta-state distance, as compared to HC. Dynamic connectivity changes characterize preclinical FTD, arguing for the desynchronization of the inner fluctuations of the brain. These changes antedate clinical symptoms, and might represent an early signature of FTD to be used as a biomarker in clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.