ArticlePloS one2019
Dynamic distribution of gallbladder microbiota in rabbit at different ages and health states.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intestinal microbiota and biliary system diseases.Frontiers in cellular and infection microbiology · 2024Pooled it
- A systematic review on omics data (metagenomics, metatranscriptomics, and metabolomics) in the role of microbiome in gallbladder disease.Frontiers in physiology · 2022Pooled it
- Gut microbiota variations over the lifespan and longevity in rabbit's maternal lines.Scientific reports · 2025Article
- Characteristics of gallbladder microbiome in healthy dogs and cats, dogs with gallbladder mucocele, and cats with suspected cholangitis/cholangiohepatitis.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2024Article
- Study on Changes in Gut Microbiota and Microbiability in Rabbits at Different Developmental Stages.Animals : an open access journal from MDPI · 2024Article
- Microbiome composition as a potential predictor of longevity in rabbits.Genetics, selection, evolution : GSE · 2024Article
- Screening of bacterial DNA in bile sampled from healthy dogs and dogs suffering from liver- or gallbladder-associated disease.The Journal of veterinary medical science · 2022Article
- Bile Collected From the Normal Gallbladder of Patients During Surgery Has Simple Bacterial Flora.Cureus · 2022Article
- Wild and Captive Environments Drive the Convergence of Gut Microbiota and Impact Health in Threatened Equids.Frontiers in microbiology · 2022Article
- Gallbladder microbiota in early vertebrates provides evolutionary insights into mucosal homeostasis.Frontiers in immunology · 2022Article
- Rabbit microbiota across the whole body revealed by 16S rRNA gene amplicon sequencing.BMC microbiology · 2021Article
- Effect of Fermented Rapeseed Meal on the Gastrointestinal Microbiota and Immune Status of Rabbit (Animals : an open access journal from MDPI · 2021Article
- Analysis of the Intestinal Flora in Male Versus Female Swamp Eels (Frontiers in microbiology · 2020Article
- Uncovering the microbiome of invasive sympatric European brown hares and European rabbits in Australia.PeerJ · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The internal environment of the gallbladder has been considered extremely unfavorable for bacterial growth, and the microbial profile of the gallbladder still unknown. By high-throughput sequencing of the bacterial 16S rRNA gene, we studied the microbial profile of the gallbladder from healthy rabbits before and after weaning. Moreover, we investigated the difference of microbiota between the gallbladder and gut. Our results showed that the gallbladder was dominantly populated by Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria in the phylum throughout the developmental stages of rabbits. The adult rabbits showed higher species richness and exhibited higher bacterial diversity than rabbits before weaning based on the results of alpha diversity. Beta diversity analyses indicated differences in the bacterial community composition between different developmental stages. In the comparison of the gallbladder and feces, Firmicutes and Bacteroidetes were dominant in the phylum, as they were present in about 61% and 21% of the feces, respectively. Conversely, in the gallbladder, Firmicutes was the most dominant (about 41%), and Bacteroidetes and Proteobacteria were present in about 16% and 22% of the gallbladder, respectively. The Unweighted UniFrac Principal Coordinate Analysis results illustrated samples clustered into 2 categories: the gallbladder and feces. Our study might provide a foundation for knowledge on gallbladder microbiota for the first time and a basis for further studies on gallbladder and intestinal health.
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