ArticlePloS one2019
Exploring the effects of electrospun fiber surface nanotopography on neurite outgrowth and branching in neuron cultures.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- A Sustainable Alternative to PVDF for Neural Tissue Engineering via Piezoelectric PHBV and Cellulose Acetate Fibers.ACS biomaterials science & engineering · 2026Article
- Controlled deposition of human neural stem cells on fiber substrates using gel encapsulation.PloS one · 2026Article
- Neural growth patterns: how random and aligned fibers guide 3D cell organization and pseudospheroid formation.Frontiers in bioengineering and biotechnology · 2025Article
- Development of Tissue-Engineered Model of Fibrotic Scarring after Spinal Cord Injury to Study Astrocyte Activation and Neurite Outgrowth In Vitro.ACS biomaterials science & engineering · 2024Article
- Recent progresses in neural tissue engineering using topographic scaffolds.American journal of stem cells · 2024Review
- Dynamic characteristics and reinforcement mechanism of silty soil improved by regenerated fiber polymer.Scientific reports · 2023Article
- Neuro-regenerative behavior of adipose-derived stem cells in aligned collagen I hydrogels.Materials today. Bio · 2023Article
- Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models.International journal of molecular sciences · 2023Review
- Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives.Pharmaceutics · 2023Review
- Piezoelectric biomaterials for neural tissue engineering.Smart medicine · 2023Review
- The Role of Tissue Geometry in Spinal Cord Regeneration.Medicina (Kaunas, Lithuania) · 2022Review
- The emerging role of mechanical and topographical factors in the development and treatment of nervous system disorders: dark and light sides of the force.Pharmacological reports : PR · 2021Review
- Assessing the combination of magnetic field stimulation, iron oxide nanoparticles, and aligned electrospun fibers for promoting neurite outgrowth from dorsal root ganglia in vitro.Acta biomaterialia · 2021Article
- ECM-Mimetic Nylon Nanofiber Scaffolds for Neurite Growth Guidance.Nanomaterials (Basel, Switzerland) · 2021Article
- Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration.Bioengineering (Basel, Switzerland) · 2020Review
- Article
- An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering.Advanced functional materials · 2020Article
- Coating Topologically Complex Electrospun Fibers with Nanothin Silk Fibroin Enhances Neurite Outgrowth in Vitro.ACS biomaterials science & engineering · 2020Article
- Aligned Fingolimod-Releasing Electrospun Fibers Increase Dorsal Root Ganglia Neurite Extension and Decrease Schwann Cell Expression of Promyelinating Factors.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Three aligned, electrospun fiber scaffolds with unique surface features were created from poly-L-lactic acid (PLLA). Fibers without surface nanotopography (smooth fibers), fibers with surface divots (shallow pits), and fibers with surface pits (deeper pits) were fabricated, and fiber alignment, diameter, and density were characterized using scanning electron microscopy (SEM). Whole dorsal root ganglia (DRG) were isolated from rats and placed onto uncoated fibers or fibers coated with laminin. On uncoated fibers, neurite outgrowth was restricted by fibers displaying divoted or pitted nanotopography when compared to neurite outgrowth on smooth fibers. However, neurites extending from whole DRG cultured on laminin-coated fibers were not restricted by divoted or pitted surface nanotopography. Thus, neurites extending on laminin-coated fibers were able to extend long neurites even in the presence of surface divots or pits. To further explore this result, individual neurons isolated from dissociated DRG were seeded onto laminin-coated smooth, pitted, or divoted fibers. Interestingly, neurons on pitted or divoted fibers exhibited a 1.5-fold increase in total neurite length, and a 2.3 or 2.7-fold increase in neurite branching compared to neurons on smooth fibers, respectively. Based on these findings, we conclude that fiber roughness in the form of pits or divots can promote extension and branching of long neurites along aligned electrospun fibers in the presence of an extracellular matrix protein coating. Thus, aligned, electrospun fibers can be crafted to not only direct the extension of axons but to induce unique branching morphologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.