ArticlePLoS genetics2019
Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 97 citations in OpenAlex.
- Species-specific brain transcriptomic responses to clothianidin and sulfoxaflor in pollinators.iScience · 2026Article
- Insecticide exposure alters feeding and impairs ovary development in a solitary bee.Ecotoxicology (London, England) · 2026Article
- A Chromosome-Level Genome Assembly and Resequencing Data Reveal Low DNA Methylation and Reduced Diversity in the Solitary Bee Pollinator Osmia cornuta.Genome biology and evolution · 2026Article
- Insecticide susceptibility of Japanese mason bees (Journal of pesticide science · 2025Article
- Chromosome-level genome assembly of Protandrena (Anthemurgus) passiflorae (Hymenoptera: Andrenidae), a host-plant specialist bee.G3 (Bethesda, Md.) · 2025Article
- Chromosome-level genome of Osmia excavata (Hymenoptera: Megachilidae) provides insights into low-temperature tolerance of Osmia pollinator.Journal of economic entomology · 2025Article
- Field-evolved resistance to neonicotinoids in the mosquito, Anopheles gambiae, is associated with mutations of nicotinic acetylcholine receptor subunits combined with cytochrome P450-mediated detoxification.Pesticide biochemistry and physiology · 2024Article
- Field-evolved resistance to neonicotinoids in the mosquito,bioRxiv : the preprint server for biology · 2024Article
- A new exposure protocol adapted for wild bees reveals species-specific impacts of the sulfoximine insecticide sulfoxaflor.Ecotoxicology (London, England) · 2024Article
- Article
- Effect of Acetamiprid, a Neonicotinoid Insecticide, on Locomotor Activity of the American Cockroach.Insects · 2024Article
- Article
- A cytochrome P450 insecticide detoxification mechanism is not conserved across the Megachilidae family of bees.Evolutionary applications · 2024Article
- Risk assessment requires several bee species to address species-specific sensitivity to insecticides at field-realistic concentrations.Scientific reports · 2023Article
- The power of Drosophila genetics in studying insect toxicology and chemical ecology.Crop health · 2023Review
- Influence of social lifestyles on host-microbe symbioses in the bees.Ecology and evolution · 2023Article
- Evolution of five environmentally responsive gene families in a pine-feeding sawfly,Ecology and evolution · 2023Article
- Genome-Wide Identification and Expression Analysis of the Cytochrome P450 Gene Family inInternational journal of molecular sciences · 2023Article
- Using physiology to better support wild bee conservation.Conservation physiology · 2023Article
- Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
Abstract
The impact of pesticides on the health of bee pollinators is determined in part by the capacity of bee detoxification systems to convert these compounds to less toxic forms. For example, recent work has shown that cytochrome P450s of the CYP9Q subfamily are critically important in defining the sensitivity of honey bees and bumblebees to pesticides, including neonicotinoid insecticides. However, it is currently unclear if solitary bees have functional equivalents of these enzymes with potentially serious implications in relation to their capacity to metabolise certain insecticides. To address this question, we sequenced the genome of the red mason bee, Osmia bicornis, the most abundant and economically important solitary bee species in Central Europe. We show that O. bicornis lacks the CYP9Q subfamily of P450s but, despite this, exhibits low acute toxicity to the N-cyanoamidine neonicotinoid thiacloprid. Functional studies revealed that variation in the sensitivity of O. bicornis to N-cyanoamidine and N-nitroguanidine neonicotinoids does not reside in differences in their affinity for the nicotinic acetylcholine receptor or speed of cuticular penetration. Rather, a P450 within the CYP9BU subfamily, with recent shared ancestry to the Apidae CYP9Q subfamily, metabolises thiacloprid in vitro and confers tolerance in vivo. Our data reveal conserved detoxification pathways in model solitary and eusocial bees despite key differences in the evolution of specific pesticide-metabolising enzymes in the two species groups. The discovery that P450 enzymes of solitary bees can act as metabolic defence systems against certain pesticides can be leveraged to avoid negative pesticide impacts on these important pollinators.
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