ArticleHuman brain mapping2019
Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Neurovascular-metabolic coupling links hearing loss to cognitive impairment: Evidence from GABA and cerebral blood flow in presbycusis.Neurobiology of disease · 2026Article
- Dementia and hearing loss: from risk to mechanisms and management.Frontiers in dementia · 2026Review
- A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study.Journal of otology · 2025Article
- Network control theory applied to the human connectome: A study on variability and discriminability of fMRI connectomic features under normal and defective sensorineural conditions.Network neuroscience (Cambridge, Mass.) · 2025Article
- Dehydration-associated cerebral hypoperfusion in sudden sensorineural hearing loss: an arterial spin labeling-based preliminary study.Frontiers in neurology · 2025Article
- Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis.Brain communications · 2024Article
- The impact of Alzheimer's disease risk factors on the pupillary light response.Frontiers in neuroscience · 2023Review
- The genetic contribution of the X chromosome in age-related hearing loss.Frontiers in genetics · 2023Article
- Global characteristics and trends of presbycusis research from 2002 to 2021: a bibliometric study.American journal of translational research · 2023Article
- High-Frequency Hearing Loss Is Associated With Anxiety and Brain Structural Plasticity in Older Adults.Frontiers in aging neuroscience · 2022Article
- Cerebral Blood Flow Pattern Changes in Unilateral Sudden Sensorineural Hearing Loss.Frontiers in neuroscience · 2022Article
- Hearing Loss and Cognitive Impairment: Epidemiology, Common Pathophysiological Findings, and Treatment Considerations.Life (Basel, Switzerland) · 2021Review
- Auditory cortex hypoperfusion: a metabolic hallmark in Beta Thalassemia.Orphanet journal of rare diseases · 2021Article
- Neuropsychological profile of hearing-impaired patients and the effect of hearing aid on cognitive functions: an exploratory study.Scientific reports · 2021Article
- Decreased resting perfusion in precuneus and posterior cingulate cortex predicts tinnitus severity.Current research in neurobiology · 2021Article
- A Proposed Hypothesis on Dementia: Inflammation, Small Vessel Disease, and Hypoperfusion Is the Sequence That Links All Harmful Lifestyles to Cognitive Impairment.Frontiers in aging neuroscience · 2021Review
- Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis.Frontiers in aging neuroscience · 2021Article
- Sub-Clinical Effects of Chronic Noise Exposure on Vestibular System.Translational medicine @ UniSa · 2020Article
- Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI.Human brain mapping · 2019Article
- Auditory-Verbal Processing Disorder and Dyslexia in Adulthood.Translational medicine @ UniSaArticle
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related hearing loss (HL) can be related to brain dysfunction or structural damage and may result in cerebral metabolic/perfusion abnormalities. Arterial spin labeling (ASL) magnetic resonance imaging (MRI) allows investigating noninvasively brain perfusion changes. Pseudocontinuous ASL and T1-weighted MRI (at 3 T) and neuropsychological testing (Montreal Cognitive Assessment) were performed in 31 HL (age range = 47-77 years, mean age ± SD = 63.4 ± 8.4 years, pure-tone average [PTA] HL > 50 dB) and 28 normal hearing (NH; age range = 48-78 years, mean age ± SD = 59.7 ± 7.4 years) subjects. Cerebral blood flow (CBF) and gray matter volume (GMV) were analyzed in the cortical volume to assess perfusion and structural group differences. Two HL subjects showing cognitive impairment were excluded from group comparisons. No significant differences in either global or local atrophy were detected between groups but the HL group exhibited significant regional effects of reduced perfusion within the bilateral primary auditory cortex, with maximal CBF difference (-17.2%) in the right lateral Heschl's gyrus. For the whole sample of HL and NH subjects (n = 59 = 31 HL + 28 NH), the regional CBF was correlated positively to the regional GMV (p = 0.020). In HL subjects (n = 31), the regional CBF was correlated negatively to the audiogram steepness (frequency range: 2-4 kHz, right ear: p = 0.022, left ear: p = 0.015). The observed cortical pattern of perfusion reduction suggests that neuronal metabolism can be related to HL before the recognition of brain structural damage. This also illustrates the potential of ASL-MRI to contribute early functional markers of reduced central processing associated with HL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.