Evidence map›Paper›PMID 30715745›Full record

ArticleJournal of medical virology2019

Th17 serum cytokines in relation to laboratory-confirmed respiratory viral infection: A pilot study.

Emmanouil Antalis, Aris Spathis, Christine Kottaridi, Athanasios Kossyvakis, Kalliopi Pastellas, Konstantinos Tsakalos, Andreas Mentis, Christos Kroupis, Sotirios Tsiodras

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Emmanouil Antalis4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.
Aris Spathis2nd Department of Pathology, University of Athens Medical School, Athens, Greece.
Christine Kottaridi2nd Department of Pathology, University of Athens Medical School, Athens, Greece.
Athanasios KossyvakisNational Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece.
Kalliopi Pastellas4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.
Konstantinos Tsakalos4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.
Andreas MentisNational Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, Athens, Greece.
Christos KroupisDepartment of Clinical Biochemistry, University of Athens Medical School, Athens, Greece.
Sotirios Tsiodras4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.ORCID 0000-0002-0463-4321
National and Kapodistrian University of Athens · GRPasteur Hellenic Institute · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTh17 cytokines are associated with modulation of inflammation and may be beneficial in clearing influenza infection in experimental models. The Th17 cytokine profile was evaluated in a pilot study of respiratory virus infections.

methodsConsecutive patients with symptoms of respiratory tract infection visiting the emergency department of a tertiary care hospital during the winter influenza season of 2014 to 2015 were evaluated. CLART PneumoVir kit, (GENOMICA, Madrid, Spain) was used for viral detection of all known respiratory viruses. Th17 cytokine profile was evaluated with the MILLIPLEX MAP Human TH17 Magnetic Bead Panel (Millipore Corp., Billerica, MA). Correlation of the TH17 profile with viral detection was performed with univariate and multivariate analysis.

resultsSeventy-six patients were evaluated (median age 56 years, 51.3% female); a respiratory virus was identified in 60 (78.9%) patients; 45% had confirmed influenza. Influenza A (H3N2) correlated with higher levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 1β (IL-1β), IL-17A, IL-17E, IL-17F, IL-21, IL-22, and IL-23 (P < 0.05 by analysis of variance [ANOVA]) compared with respiratory syncytial virus (RSV). Parainfluenza virus (PIV) similarly had higher levels of GM-CSF, IL-1b, IL-17A, IL-22 compared with those detected in RSV, influenza B and any other virus infection ( P < 0.05; ANOVA). Increasing age (β-coefficient = 1.11, 95% CI, 1.04-1.2, P < 0.01) as well as IL-17A levels (β-coefficient = 1.03, 95% CI, 1.001-1.05, P = 0.04) predicted hospital admission.

conclusionMain Th17 cell effector cytokines were upregulated in laboratory-confirmed A(H3N2) influenza and PIV. Excessive amounts of Th17 cytokines may be implicated in the pathogenesis and immune control of acute influenza and PIV infection in humans and may predict the severity of disease.

Indexed as

AdultAgedCytokinesFemaleHumansInterleukin-17Interleukin-21Interleukin-22Interleukin-23InterleukinsMaleMiddle AgedPilot ProjectsRespiratory Tract InfectionsSpainTh17 CellsCytokinesInterleukin-17Interleukin-21Interleukin-22Interleukin-23InterleukinsIL-17influenzaRSVTh17

Identifiers

PMID30715745
PMCPMC7166444
OpenAlexW2913530550

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.