ArticleEJNMMI research2019
Partial-volume correction in dynamic PET-CT: effect on tumor kinetic parameter estimation and validation of simplified metrics.
Article in EJNMMI research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- PET/CT-Based Response Evaluation in Cancer-a Systematic Review of Design Issues.Molecular imaging and biology · 2020Pooled it
- Role of PET imaging in evaluating right ventricular function and prognosis in pulmonary hypertension.Clinics (Sao Paulo, Brazil) · 2026Review
- Toward an optimized PET reconstruction protocol for spinal cord: superiority of OSEM with TOF and PSF.EJNMMI physics · 2026Article
- Critical review of partial volume correction methods in PET and SPECT imaging: benefits, pitfalls, challenges, and future outlook.European journal of nuclear medicine and molecular imaging · 2026Review
- Role of FDG-PET/CT in detecting metabolic changes in parotid glands following photon versus proton therapy.American journal of nuclear medicine and molecular imaging · 2026Article
- Lower Extremity Flow Quantification Using DynamicIEEE transactions on radiation and plasma medical sciences · 2025Article
- Dual-Time-PointBMC cancer · 2025Article
- Human dose-escalation study of PET imaging CD8European journal of nuclear medicine and molecular imaging · 2025Article
- Impact of hyperglycemia and antidiabetic medication on pancreatic uptake on [Frontiers in endocrinology · 2025Article
- Deep learning-based partial volume correction in standard and low-dose positron emission tomography-computed tomography imaging.Quantitative imaging in medicine and surgery · 2024Article
- Validation of image-derived input function using a long axial field of view PET/CT scanner for two different tracers.EJNMMI physics · 2024Article
- Clinical feasibility study of early 30-minute dynamic FDG-PET scanning protocol for patients with lung lesions.EJNMMI physics · 2024Article
- A cycle-consistent adversarial network for brain PET partial volume correction without prior anatomical information.European journal of nuclear medicine and molecular imaging · 2023Article
- Immunocyte count combined with CT features for distinguishing pulmonary tuberculoma from malignancy among non-calcified solitary pulmonary solid nodules.Journal of thoracic disease · 2023Article
- Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2022Article
- Proof of concept of a multimodal intravital molecular imaging system for tumour transpathology investigation.European journal of nuclear medicine and molecular imaging · 2022Article
- Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2020Article
- Spatially-variant image-based modeling of PSF deformations with application to a limited angle geometry from a dual-panel breast-PET imager.Physics in medicine and biology · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundPartial-volume effects generally result in an underestimation of tumor tracer uptake on PET-CT for small lesions, necessitating partial-volume correction (PVC) for accurate quantification. However, investigation of PVC in dynamic oncological PET studies to date is scarce. The aim of this study was to investigate PVC's impact on tumor kinetic parameter estimation from dynamic PET-CT acquisitions and subsequent validation of simplified semi-quantitative metrics. Ten patients with EGFR-mutated non-small cell lung cancer underwent dynamic
resultsPVC had a non-linear effect on measured activity concentrations per timeframe. PVC significantly changed each kinetic parameter, with a median increase in V
conclusionPVC has a significant impact on tumor kinetic parameter estimation from dynamic PET-CT data, which differs from its effect on simplified metrics. However, it affected validation of these simplified metrics both as single measurements and as biomarkers of treatment response only to a small extent. Future dynamic PET studies should preferably incorporate PVC.
trial registrationDutch Trial Register, NTR3557 .
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