ArticlePediatric nephrology (Berlin, Germany)2019
Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children.
Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Creatinine-to-cystatin C ratio as muscle assessment tool and predictive value for mortality and sarcopenia in patients with chronic kidney disease: a meta-analysis.Frontiers in nutrition · 2025Pooled it
- Serum creatinine/cystatin C ratio as a muscle mass evaluating tool and prognostic indicator for hospitalized patients: A meta-analysis.Frontiers in medicine · 2022Pooled it
- IPNA clinical practice recommendations for the diagnosis and management of children with steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2020Guideline
- The association between cystatin C and COPD: a meta-analysis and systematic review.BMC pulmonary medicine · 2020Pooled it
- Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis.International journal of environmental research and public health · 2020Pooled it
- Gold Standard GFR measurement and GFR estimation in pediatric oncology - indications and limitations.Pediatric nephrology (Berlin, Germany) · 2026Review
- Sarcopenia index (serum creatinine/cystatin C ratio) independently identifies sarcopenia risk and mortality in older hospitalized patients with type 2 diabetes mellitus: a retrospective analysis.Frontiers in endocrinology · 2026Article
- Creatinine-based formulas are not ideal to estimate glomerular filtration rate in selected pediatric patients: data from a tertiary pediatric nephrology center.Pediatric nephrology (Berlin, Germany) · 2024Article
- A Comparative Study on the Efficacy Between Cystatin C and Creatinine-Based Equations for Early Detection of Renal Damage in Patients of Eastern India.Indian journal of clinical biochemistry : IJCB · 2024Article
- Extending the cystatin C based EKFC-equation to children - validation results from Europe.Pediatric nephrology (Berlin, Germany) · 2024Article
- New race-free creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate and association with cardiovascular mortality in the AtheroGene study.Internal and emergency medicine · 2024Article
- Application of GFR estimating equations to children with normal, near-normal, or discordant GFR.Pediatric nephrology (Berlin, Germany) · 2023Article
- Cystatin C as a Marker for Glomerular Filtration Rate in Critically Ill Neonates and Children: Validation Against Iohexol Plasma Clearance.Kidney international reports · 2023Article
- Fetal growth restriction followed by very preterm birth is associated with smaller kidneys but preserved kidney function in adolescence.Pediatric nephrology (Berlin, Germany) · 2023Article
- Impaired renal clearance among Swedish adolescents born preterm.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- The role of urinary N-acetyl-β-D-glucosaminidase in early detection of acute kidney injury among pediatric patients with neoplastic disorders in a retrospective study.BMC pediatrics · 2022Article
- Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes.Scientific reports · 2022Article
- Acute kidney injury in pediatric hematopoietic cell transplantation: critical appraisal and consensus.Pediatric nephrology (Berlin, Germany) · 2022Review
- Population pharmacokinetic and dose optimization of mycophenolic acid in children with anti-neutrophilic cytoplasmic antibody-associated nephritis.European journal of clinical pharmacology · 2022Article
- Cystatin C relates to metabolism in healthy, pubertal adolescents.Pediatric nephrology (Berlin, Germany) · 2022Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from several European medical centres.
methodsThree thousand four hundred eight measurements of GFR (mGFR) using plasma clearance of exogenous substances were performed in 2218 children aged 2-17 years. Validated equations included Schwartz-2009
resultsThree of the cystatin C equations, Berg
conclusionsThe present study strongly suggests that cystatin C should be the primary biomarker of choice when estimating GFR in children with decreased GFR. Arithmetic means of well-performing single-marker equations improve accuracy further at most mGFR levels and have practical advantages compared to composite equations.
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