ArticleEuropean radiology2019
Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01754012 (New Dietary Strategies Addressing the Specific Needs of Elderly Population for an Healthy Aging in Europe), which is not on this map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
New Dietary Strategies Addressing the Specific Needs of Elderly Population for an Healthy Aging in Europe
Who cites it
30 citing papers in PubMed.
- Effect of synbiotic supplementation on immune parameters and gut microbiota in healthy adults: a double-blind randomized controlled trial.Gut microbes · 2023Trial
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- Gender differences in adiponectin levels among obese individuals and their association with cardiovascular disease.Frontiers in cell and developmental biology · 2026Review
- Assessment of Health-Related Quality of Life and Biomarkers in Long COVID: A 12-Month Longitudinal Feasibility Cohort.Journal of clinical medicine · 2025Article
- Toward precision interventions and metrics of inflammaging.Nature aging · 2025Review
- Sex Specificities in the Association Between Diet, Physical Activity, and Body Composition Among the Elderly: A Cross-Sectional Study in Florence, Italy.International journal of environmental research and public health · 2025Article
- Sex-specific prognostic utility of the sarcopenia index in all-cause mortality risk for patients with heart failure.Frontiers in nutrition · 2025Article
- Targeting Crosstalk of Signaling Pathways among Muscles-Bone-Adipose Tissue: A Promising Therapeutic Approach for Sarcopenia.Aging and disease · 2024Review
- Association between systemic inflammatory response index and bone turnover markers in Chinese patients with osteoporotic fractures: a retrospective cross-sectional study.Frontiers in medicine · 2024Article
- Review
- Inter-Examiner Disagreement for Assessing Cervical Multifidus Ultrasound Metrics Is Associated with Body Composition Features.Sensors (Basel, Switzerland) · 2023Article
- Correlation between Body Composition and Inter-Examiner Errors for Assessing Lumbar Multifidus Muscle Size, Shape and Quality Metrics with Ultrasound Imaging.Bioengineering (Basel, Switzerland) · 2023Article
- Gender Differences and Cardiometabolic Risk: The Importance of the Risk Factors.International journal of molecular sciences · 2023Review
- Quantification of chemotherapy-induced changes in body composition in pediatric, adolescent, and young adult lymphoma using standard of care CT imaging.European radiology · 2022Article
- Osteosarcopenic obesity and its components-osteoporosis, sarcopenia, and obesity-are associated with blood cell count-derived inflammation indices in older Chinese people.BMC geriatrics · 2022Article
- The Relationship between Empirical Dietary Inflammatory Pattern with Anthropometric Measures in Women with Overweight and Obesity: A Cross-Sectional Study.Iranian journal of public health · 2022Article
- The association between dietary inflammatory index, muscle strength, muscle endurance, and body composition in Iranian adults.Eating and weight disorders : EWD · 2022Article
- Sarcopenia, immune-mediated rheumatic diseases, and nutritional interventions.Aging clinical and experimental research · 2021Review
- Article
- Association between Dietary Inflammatory Index with Bioelectrical Impedance Parameters and Characteristics Health in Overweight/Obese Women: A Cross-Sectional Study.International journal of preventive medicine · 2021Article
Corrections and comments
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Authors and funding
24 authors.
Funding
Abstract
objectivesThe aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.
methodsA whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65-79 years) women and men from five European countries of the "New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe" project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays.
resultsBC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.
conclusionsThe association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice. KEY POINTS: • Body composition markers concordantly associated positively or negatively with adipose-related and inflammatory markers, with the exception of skeletal muscle mass index. • No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, gp130, TNF-α-R1, and TNF-α-R2. • Skeletal muscle mass index (SMI) shows a good correlation with inflammatory profile in age-related sarcopenia.
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