ArticleToxicological sciences : an official journal of the Society of Toxicology2019
Extracting and Benchmarking Emerging Adverse Outcome Pathway Knowledge.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Unveiling toxicological adverse outcomes: toward construction and simulation of large-scale networks.Toxicological sciences : an official journal of the Society of Toxicology · 2026Review
- Adverse Outcome Pathways Mechanistically Describing Hepatotoxicity.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives.Archives of toxicology · 2024Article
- Development of an adverse outcome pathway network for nephrotoxicity.Archives of toxicology · 2024Article
- Why adverse outcome pathways need to be FAIR.ALTEX · 2024Article
- Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps.Frontiers in toxicology · 2024Article
- Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays.Neurotoxicology · 2023Review
- Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption.Toxicological sciences : an official journal of the Society of Toxicology · 2023Review
- Defining the Biologically Plausible Taxonomic Domain of Applicability of an Adverse Outcome Pathway: A Case Study Linking Nicotinic Acetylcholine Receptor Activation to Colony Death.Environmental toxicology and chemistry · 2023Article
- Assessment of endocrine disruptive properties of PFOS: EFSA/ECHA guidance case study utilising AOP networks and alternative methods.EFSA journal. European Food Safety Authority · 2022Article
- From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study.Frontiers in toxicology · 2022Article
- A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment.Nanotoxicology · 2021Article
- Collaborative efforts are needed among the scientific community to advance the adverse outcome pathway concept in areas of radiation risk assessment.International journal of radiation biology · 2021Article
- An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac.Archives of toxicology · 2020Article
- Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale.Particle and fibre toxicology · 2020Review
- Quantitative adverse outcome pathway (qAOP) models for toxicity prediction.Archives of toxicology · 2020Review
- Modernization of chemical risk assessment to make use of novel toxicological data.Toxicology and applied pharmacology · 2020Article
- Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Adverse Outcome Pathways: Moving from a Scientific Concept to an Internationally Accepted Framework.Environmental toxicology and chemistry · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
As the community of toxicological researchers, risk assessors, and risk managers adopt the adverse outcome pathway (AOP) framework for organizing toxicological knowledge, the number and diversity of AOPs in the online AOP knowledgebase (KB) continues to grow. To track and investigate this growth, AOPs in the AOP-KB were assembled into a single network. Summary measures on the current state of the AOP-KB and the overall connectivity and structural features of the resulting network were calculated. Our results show that networking the 187 user-defined AOPs currently described in the AOP-KB resulted in the emergence of 9405 unique, previously undescribed, linear AOPs (LAOPs). To investigate patterns in this emerging knowledge, we assembled the AOP-KB network retrospectively by sequentially adding each of the 187 user-defined AOPs and found that the creation of new AOPs that borrowed components from previously existing AOPs in the KB most described emergence of new LAOPs. However, the introduction of nonadjacent key event relationships and cycles among KEs also play key roles in emergent LAOPs. We provide examples of how to identify application-specific critical paths from this large number of LAOPs. Our research shows that the global AOP network may have considerable value as a source of emergent toxicological knowledge. These findings are not only helpful for understanding the nature of this emergent information but can also be used to manage and guide future development of the AOP-KB, and how to tailor this wealth of information to specific applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.