Evidence map›Paper›PMID 30715467›Full record

ArticleThe Journal of infectious diseases2019

Dynamic Perspectives on the Search for a Universal Influenza Vaccine.

Chadi M Saad-Roy, Adrian B McDermott, Bryan T Grenfell

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Monitoring Influenza A Virus Entry Using Quantitative Fluorescence Microscopy.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Targeted vaccination and the speed of SARS-CoV-2 adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Human Influenza Epidemiology.Cold Spring Harbor perspectives in medicine · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes.medRxiv : the preprint server for health sciences · 2021
    Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chadi M Saad-RoyLewis-Sigler Institute for Integrative Genomics.
Adrian B McDermottVaccine Research Center, National Institute of Allergy and Infectious Diseases.
Bryan T GrenfellDepartment of Ecology and Evolutionary Biology, Princeton University, New Jersey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A universal influenza vaccine (UIV) could considerably alleviate the public health burden of both seasonal and pandemic influenza. Although significant progress has been achieved in clarifying basic immunology and virology relating to UIV, several important questions relating to the dynamics of infection, immunity, and pathogen evolution remain unsolved. In this study, we review these gaps, which span integrative levels, from cellular to global and timescales from molecular events to decades. We argue that they can be best addressed by a tight integration of empirical (laboratory, epidemiological) research and theory and suggest fruitful areas for this synthesis. In particular, quantifying natural and vaccinal limitations on viral transmission are central to this effort.

Indexed as

Computational BiologyCross ProtectionHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A virusInfluenza B virusInfluenza, HumanInfluenza VaccinesModels, TheoreticalPandemicsPhylogenyVaccinationHemagglutinin Glycoproteins, Influenza VirusInfluenza Vaccinesinfluenza vaccinationshedding-transmission relationshipviral eco-evolutionary dynamics

Identifiers

PMID30715467
PMCPMC6452315

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.