ArticleJournal of experimental botany2019
Homeostasis in the soybean miRNA396-GRF network is essential for productive soybean cyst nematode infections.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- The multifaceted regulatory network of microRNA396: Orchestrating plant plasticity through coordinating development and various stresses.Journal of integrative plant biology · 2026Review
- Small but big player: the important role of microRNAs in legume crops.Molecular genetics and genomics : MGG · 2026Review
- Detection of Soil-Borne Pathogens Using Fine-Tuned Deep Learning Models: A Case Study on the Soybean Cyst Nematode (Heterodera glycines Ichinohe).The plant pathology journal · 2026Article
- miRNA-Mediated Regulation ofInternational journal of molecular sciences · 2025Article
- Roles of microRNAs and histone modifications in enhancing stress tolerance in soybean and their applications in molecular breeding.Breeding science · 2025Article
- MicroRNA gatekeepers: Orchestrating rhizospheric dynamics.Journal of integrative plant biology · 2025Review
- Functional Identification of miR2119 TargetingJournal of agricultural and food chemistry · 2024Article
- Conceptual Framework of Epigenetic Analyses of Plant Responses to Sedentary Endoparasitic Nematodes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Integrated Omic Approaches Reveal Molecular Mechanisms of Tolerance during Soybean andPlants (Basel, Switzerland) · 2022Article
- Progress in soybean functional genomics over the past decade.Plant biotechnology journal · 2022Review
- Differential microRNA expression, microRNA arm switching, and microRNA:long noncoding RNA interaction in response to salinity stress in soybean.BMC genomics · 2022Article
- Article
- Soybean miR159International journal of molecular sciences · 2021Article
- MiR396-GRF module associates with switchgrass biomass yield and feedstock quality.Plant biotechnology journal · 2021Article
- smi-miR396b targeted SmGRFs, SmHDT1, and SmMYB37/4 synergistically regulates cell growth and active ingredient accumulation in Salvia miltiorrhiza hairy roots.Plant cell reports · 2020Article
- A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism.Journal of experimental botany · 2020Article
- ConservedInternational journal of molecular sciences · 2019Article
- MicroRNAs, New Players in the Plant-Nematode Interaction.Frontiers in plant science · 2019Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterodera glycines, the soybean cyst nematode, penetrates soybean roots and migrates to the vascular cylinder where it forms a feeding site called the syncytium. MiRNA396 (miR396) targets growth-regulating factor (GRF) genes, and the miR396-GRF1/3 module is a master regulator of syncytium development in model cyst nematode H. schachtii infection of Arabidopsis. Here, we investigated whether this regulatory system operates similarly in soybean roots and is likewise important for H. glycines infection. We found that a network involving nine MIR396 and 23 GRF genes is important for normal development of soybean roots and that GRF function is specified in the root apical meristem by miR396. All MIR396 genes are down-regulated in the syncytium during its formation phase while, specifically, 11 different GRF genes are up-regulated. The switch to the syncytium maintenance phase coincides with up-regulation of MIR396 and down-regulation of the 11 GRF genes specifically via post-transcriptional regulation by miR396. Furthermore, interference with the miR396-GRF6/8-13/15-17/19 regulatory network, through either overexpression or knockdown experiments, does not affect the number of H. glycines juveniles that enter the vascular cylinder to initiate syncytia, but specifically inhibits efficient H. glycines development to adult females. Therefore, homeostasis in the miR396-GRF6/8-13/15-17/19 regulatory network is essential for productive H. glycines infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.