Evidence map›Paper›PMID 30715407›Full record

ArticleThe Journal of infectious diseases2019

CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain.

Alberto A Amarilla, Nilton Nascimento Santos-Junior, Mario Luis Figueiredo, Joao Paulo Mesquita Luiz, Marcilio Jorge Fumagalli, David F Colón, Veronica Lippi, Helda Liz Alfonso, Djalma S Lima-Junior, Amanda C Trabuco and 19 more

Open access · bronzeAbstract read
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In one paragraph

Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 6 institutions in 3 countries.

Alberto A AmarillaLaboratory of Virology, Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
Nilton Nascimento Santos-JuniorDepartment of Neurosciences and Behavioral Sciences, Ribeirao Preto, SP, Brazil.
Mario Luis FigueiredoLaboratory of Virology, Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
Joao Paulo Mesquita LuizCenter for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirao Preto, SP, Brazil.
Marcilio Jorge FumagalliVirology Research Center, Ribeirao Preto, SP, Brazil.
David F ColónCenter for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirao Preto, SP, Brazil.
Veronica LippiLaboratory of Virology, Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
Helda Liz AlfonsoLaboratory of Virology, Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
Djalma S Lima-JuniorDepartment of Biochemistry and Immunology, Ribeirao Preto Medical School, Ribeirao Preto, SP, Brazil.
Amanda C TrabucoLaboratory of Virology, Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
Richard L SpinieliDepartment of Psychology, School of Philosophy, Science and Literature of Ribeirao Preto of the University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Amanda C DesideraDepartment of Psychology, School of Philosophy, Science and Literature of Ribeirao Preto of the University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Christie R A Leite-PanissiDepartment of Psychology, School of Philosophy, Science and Literature of Ribeirao Preto of the University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Flávio LaurettiVirology Research Center, Ribeirao Preto, SP, Brazil.
Silvia Elena Sánchez MendozaDivision of Hematology, Department of Internal Medicine, Ribeirao Preto, SP, Brazil.
Cleide Lúcia Araújo SilvaRibeirao Preto Regional Blood Center, Ribeirao Preto, SP, Brazil.
Eduardo Magalhaes RegoDivision of Hematology, Department of Internal Medicine, Ribeirao Preto, SP, Brazil.
Leonardo J Galvao-LimaDepartment of Immunology, Ribeirão Preto Medical School University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Gabriel S BassiDepartment of Pharmacology, Ribeirão Preto Medical School University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Sandra L B Penharvel MartínsDepartment of Surgery and Anatomy, Ribeirão Preto Medical School University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Wilson Gomez ManriqueAnimal Health Laboratory, Veterinary Medicine Course, Federal University of Rondonia - UNIR, Rolim de Moura, RO, Brazil.
José Carlos Alves-FilhoCenter for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirao Preto, SP, Brazil.
Fernando Q CunhaCenter for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirao Preto, SP, Brazil.
Nias Y G PengAustralian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
Naphak ModhiranAustralian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
Yin Xiang SetohAustralian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
Alexander A KhromykhAustralian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
Luiz T M FigueiredoVirology Research Center, Ribeirao Preto, SP, Brazil.
Victor H AquinoLaboratory of Virology, Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
Universidade de São Paulo · BRThe University of Queensland · AUClinics Hospital of Ribeirão Preto · BRUniversidade de Ribeirão Preto · BRInstituto de Neurociências e Comportamento · BRUniversidade Federal de Rondônia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rocio virus (ROCV) is a highly neuropathogenic mosquito-transmitted flavivirus responsible for an unprecedented outbreak of human encephalitis during 1975-1976 in Sao Paulo State, Brazil. Previous studies have shown an increased number of inflammatory macrophages in the central nervous system (CNS) of ROCV-infected mice, implying a role for macrophages in the pathogenesis of ROCV. Here, we show that ROCV infection results in increased expression of CCL2 in the blood and in infiltration of macrophages into the brain. Moreover, we show, using CCR2 knockout mice, that CCR2 expression is essential for macrophage infiltration in the brain during ROCV infection and that the lack of CCR2 results in increased disease severity and mortality. Thus, our findings show the protective role of CCR2-mediated infiltration of macrophages in the brain during ROCV infection.

Indexed as

AnimalsBrainBrazilEncephalitisFemaleFlavivirusFlavivirus InfectionsMacrophagesMiceMice, Inbred C57BLMice, KnockoutReceptors, CCR2Ccr2 protein, mouseReceptors, CCR2CCL2encephalitismacrophagespathogenesisROCV

Identifiers

PMID30715407
PMCPMC7107438
OpenAlexW2912249578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.