SynthesisEuropean heart journal. Quality of care & clinical outcomes2019
Right ventricular pacing for hypertrophic obstructive cardiomyopathy: meta-analysis and meta-regression of clinical trials.
Synthesis in European heart journal. Quality of care & clinical outcomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05257772 (Electromechanically Optimised Right Ventricular Pacing In Hypertrophic Cardiomyopathy), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electromechanically Optimised Right Ventricular Pacing In Hypertrophic Cardiomyopathy (EMORI-HCM)
Who cites it
8 citing papers in PubMed.
- Suicide left ventricle triggered by accelerated junctional rhythm after transcatheter aortic valve implantation: a case report of rhythm-dependent dynamic left ventricular outflow tract obstruction.European heart journal. Case reports · 2026Article
- Vasopressin role in hypertrophic obstructive cardiomyopathy post-cardiac surgery: A case report.World journal of critical care medicine · 2025Article
- Validation of a Curricular Map on Cardiac Implantable Electronic Devices (CIEDs) for Cardiac Anesthesia Trainees.Cureus · 2025Article
- High-Precision Hemodynamic and Echocardiographic Assessment of Pacing in Obstructive Hypertrophic Cardiomyopathy.Pacing and clinical electrophysiology : PACE · 2025Article
- Hypokinetic hypertrophic cardiomyopathy: clinical phenotype, genetics, and prognosis.ESC heart failure · 2022Article
- 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Article
- Targeted Medical Therapies for Hypertrophic Cardiomyopathy.Current cardiology reports · 2020Review
- Discriminating electrocardiographic responses to His-bundle pacing using machine learning.Cardiovascular digital health journalArticle
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Authors and funding
16 authors.
Funding
Abstract
aimsRight ventricular pacing for left ventricular outflow tract gradient reduction in hypertrophic obstructive cardiomyopathy remains controversial. We undertook a meta-analysis for echocardiographic and functional outcomes. METHODS AND
resultsThirty-four studies comprising 1135 patients met eligibility criteria. In the four blinded randomized controlled trials (RCTs), pacing reduced gradient by 35% [95% confidence interval (CI) 23.2-46.9, P < 0.0001], but there was only a trend towards improved New York Heart Association (NYHA) class [odds ratio (OR) 1.82, CI 0.96-3.44; P = 0.066]. The unblinded observational studies reported a 54.3% (CI 44.1-64.6, P < 0.0001) reduction in gradient, which was a 18.6% greater reduction than the RCTs (P = 0.0351 for difference between study designs). Observational studies reported an effect on unblinded NYHA class at an OR of 8.39 (CI 4.39-16.04, P < 0.0001), 450% larger than the OR in RCTs (P = 0.0042 for difference between study designs). Across all studies, the gradient progressively decreased at longer follow durations, by 5.2% per month (CI 2.5-7.9, P = 0.0001).
conclusionRight ventricular pacing reduces gradient in blinded RCTs. There is a non-significant trend to reduction in NYHA class. The bias in assessment of NYHA class in observational studies appears to be more than twice as large as any genuine treatment effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.