Evidence map›Paper›PMID 30715062›Full record

ArticleMicromachines2018

An Optically Induced Dielectrophoresis (ODEP)-Based Microfluidic System for the Isolation of High-Purity CD45

Chia-Jung Liao, Chia-Hsun Hsieh, Tzu-Keng Chiu, Yu-Xian Zhu, Hung-Ming Wang, Feng-Chun Hung, Wen-Pin Chou, Min-Hsien Wu

Open access · goldAbstract read
In one paragraph

Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

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  12. Cell Separations and Sorting.Analytical chemistry · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chia-Jung LiaoGraduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City 33302, Taiwan. l329735@ms49.hinet.net.
Chia-Hsun HsiehDivision of Haematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital (Linko), Taoyuan City 33302, Taiwan. wisdom5000@gmail.com.
Tzu-Keng ChiuDepartment of Chemical and Materials Engineering, Chang Gung University, Taoyuan City 33302, Taiwan. b74225@hotmail.com.
Yu-Xian ZhuGraduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City 33302, Taiwan. maple7530@gmail.com.
Hung-Ming WangDivision of Haematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital (Linko), Taoyuan City 33302, Taiwan. whm526@adm.cgmh.org.tw.
Feng-Chun HungGraduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City 33302, Taiwan. fjiun@hotmail.com.
Wen-Pin ChouGraduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City 33302, Taiwan. d94522010@ntu.edu.tw.
Min-Hsien WuGraduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan City 33302, Taiwan. mhwu@mail.cgu.edu.tw.
Chang Gung University · TWChang Gung Memorial Hospital · TWMing Chi University of Technology · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPD2E0011-13Chang Gung Memorial Hospital, Linkou CMRPD2G0061-62Chang Gung Memorial Hospital, Linkou CMRPD2H0121Chang Gung Memorial Hospital, Linkou CMRPG3E1633Chang Gung Memorial Hospital, Linkou CMRPG3G0591-3Ministry of Science and Technology, Taiwan MOST 104-2628-E-182-002-MY3Ministry of Science and Technology, Taiwan MOST 105-2221-E-182-028-MY3
6 · The paper itself

Abstract

Circulating tumour cells (CTCs) in blood circulation play an important role in cancer metastasis. CTCs are generally defined as the cells in circulating blood expressing the surface antigen EpCAM (epithelial cell adhesion molecule). Nevertheless, CTCs with a highly metastatic nature might undergo an epithelial-to-mesenchymal transition (EMT), after which their EpCAM expression is downregulated. In current CTC-related studies, however, these clinically important CTCs with high relevance to cancer metastasis could be missed due to the use of the conventional CTC isolation methodologies. To precisely explore the clinical significance of these cells (i.e., CD45

Indexed as

cancer metastasiscell isolationcirculating tumour cells (CTCs)microfluidic systemsoptically induced dielectrophoresis (ODEP)

Identifiers

PMID30715062
PMCPMC6266761
OpenAlexW2898753004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.