ArticleMicromachines2018
Internal Structure of Matrix-Type Multilayer Capsules Templated on Porous Vaterite CaCO₃ Crystals as Probed by Staining with a Fluorescence Dye.
Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Encapsulation Strategy Matters: Pre- and Post-Loading of Macromolecules into Surface-Supported Microgels Formed via Vaterite Templates.ACS materials Au · 2025Article
- Distinctive Features of the Buffer Capacity of Polyelectrolyte Microcapsules Formed on MnCOPolymers · 2025Article
- Formulation and Biodegradation of Surface-Supported Biopolymer-Based Microgels Formed via Hard Templating onto Vaterite CaCOMaterials (Basel, Switzerland) · 2023Article
- Modification of Surfaces with Vaterite CaCOMicromachines · 2022Review
- Polyelectrolyte Multilayered Capsules as Biomedical Tools.Polymers · 2022Review
- Nanoparticle-Doped Hybrid Polyelectrolyte Microcapsules with Controlled Photoluminescence for Potential Bioimaging Applications.Polymers · 2021Article
- Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives.Nanomaterials (Basel, Switzerland) · 2021Review
- Which Biopolymers Are Better for the Fabrication of Multilayer Capsules? A Comparative Study Using Vaterite CaCOACS applied materials & interfaces · 2021Article
- Layer-By-Layer Assemblies of Biopolymers: Build-Up, Mechanical Stability and Molecular Dynamics.Polymers · 2020Review
- Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering.Micromachines · 2020Review
- Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCOMicromachines · 2020Review
- Editorial for the Special Issue on Self-Assembly of Polymers.Micromachines · 2019Article
- Porous Alginate Scaffolds Assembled Using Vaterite CaCOMicromachines · 2019Review
- Encapsulation of Long Genomic DNA into a Confinement of a Polyelectrolyte Microcapsule: A Single-Molecule Insight.ACS omega · 2019Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
Multilayer capsules templated on decomposable vaterite CaCO₃ crystals are widely used as vehicles for drug delivery. The capsule represents typically not a hollow but matrix-like structure due to polymer diffusion into the porous crystals during multilayer deposition. The capsule formation mechanism is not well-studied but its understanding is crucial to tune capsule structure for a proper drug release performance. This study proposes new approach to noninvasively probe and adjust internal capsule structure. Polymer capsules made of poly(styrene-sulfonate) (PSS) and poly(diallyldimethylammonium chloride) (PDAD) have been stained with fluorescence dye rhodamine 6G. Physical-chemical aspects of intermolecular interactions required to validate the approach and adjust capsule structure are addressed. The capsules consist of a defined shell (typically 0.5⁻2 µm) and an internal matrix of PSS-PDAD complex (typically 10⁻40% of a total capsule volume). An increase of ionic strength and polymer deposition time leads to the thickening of the capsule shell and formation of a denser internal matrix, respectively. This is explained by effects of a polymer conformation and limitations in polymer diffusion through the crystal pores. We believe that the design of the capsules with desired internal structure will allow achieving effective encapsulation and controlled/programmed release of bioactives for advanced drug delivery applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.