ArticleExperimental and clinical psychopharmacology2019
Pack-years of tobacco cigarette smoking as a predictor of spontaneous pain reporting and experimental pain reactivity.
Article in Experimental and clinical psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- Association Between Smoking and Opioid Requirement and Pain Intensity in the Early Postoperative Period: A Meta-Analysis.Pain and therapy · 2026Article
- A biopsychosocial path model linking tobacco smoking to the Native American chronic pain disparity: findings from the Oklahoma Study of Native American Pain Risk.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2026Observational
- Prevalence of PD-1 Inhibitor-Associated Peripheral Neuropathy: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2025Article
- Smoking Cessation Among Patients with Chronic Pain in a Comparative Effectiveness Trial.Journal of general internal medicine · 2025Article
- Construction and validation of the prediction model for kinesiophobia in older adults with chronic low back pain.BMC geriatrics · 2025Article
- Uncomfortable Paresthesia and Dysesthesia Following Tonic Spinal Cord Stimulator Implantation.Brain sciences · 2025Article
- Pain-Related Smoking Expectancies and Smoking Behavior Among U.S. Adult Cigarette Smokers with Chronic Pain.International journal of behavioral medicine · 2025Article
- Ecological momentary assessment of cigarette smoking behavior and pain intensity among individuals with chronic back pain who smoke.The journal of pain · 2025Article
- Article
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- A scoping review of pain and tobacco use among cancer survivors.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- UK medical cannabis registry: A clinical outcome analysis of medical cannabis therapy in chronic pain patients with and without co-morbid sleep impairment.Pain practice : the official journal of World Institute of Pain · 2025Article
- Hypovitaminosis D in patients with oral leukoplakia: insights from a cross-sectional study.Frontiers in oncology · 2025Article
- No Effect of Cigarette Smoking in the Outcome of Arthroscopic Management for Femoroacetabular Impingement: A Systematic Review.Journal of clinical medicine · 2024Review
- Ten-year cardiovascular disease risk and related factors in lifetime marijuana use with comorbid methamphetamine-associated psychotic disorder: a QRISKBMC psychiatry · 2024Article
- Pain sensitivity as a state marker and predictor for adolescent non-suicidal self-injury.Psychological medicine · 2024Article
- Association between smoking and central sensitization pain: a web-based cross-sectional study.Journal of anesthesia · 2024Article
- Pain interference among adult dual combustible and electronic tobacco users in terms of perceived barriers for quitting.Experimental and clinical psychopharmacology · 2024Article
- Thoughts about "Assessment of Quality of Diabetic Care in Teaching Hospitals in Ethiopia: In Comparison to International Guidelines" [Letter].Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Pleural fluid adenosine deaminase to serum C-reactive protein ratio for diagnosing tuberculous pleural effusion.BMC pulmonary medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The pack-years formula is a widely used estimate of lifetime tobacco smoking exposure, and greater pack-years have been associated with greater risk of chronic pain development and poorer pain-related outcomes among smokers with chronic pain. The pathophysiology underlying these associations is poorly understood. Regular tobacco smoking exposure may dysregulate homeostatic pain processes, producing an allostatic state of pain facilitation. Maladaptive pain mechanisms, such as central and peripheral sensitization, are chronic pain risk factors. Yet no published research has examined the relation between lifetime-smoking exposure and dysregulated pain processing. The current study used hierarchical linear regression analyses to test pack-years of tobacco smoking as a predictor of (a) pain reporting (current pain severity, pain frequency in the last 180 days) among a sample of 228 daily smokers without chronic pain, and (b) experimental capsaicin-induced pain reactivity (pain intensity, area of flare, mechanical pain sensitivity, and area of mechanical hyperalgesia) among 101 daily smokers without chronic pain. As hypothesized, results indicated that pack-years smoking was positively and significantly associated with current pain severity, past 180-day pain frequency, experimental pain intensity, mechanical pain sensitivity ratings, and area of mechanical hyperalgesia. Pack-years smoking was not significantly associated with neurogenic flare. These findings implicate central sensitization as a factor that may underlie the association between chronic tobacco smoking and increased risk for persistent pain. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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