ArticleJournal of the American Chemical Society2019
Sequence-Controlled Polymers Through Entropy-Driven Ring-Opening Metathesis Polymerization: Theory, Molecular Weight Control, and Monomer Design.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Sequence-Controlled Copolymers Through Selective Ring-Opening Polymerization of Multiunit Macrolactones.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Synthesis and Ring-Opening Metathesis Polymerization of Energetic Norbornene Materials.ACS polymers Au · 2026Article
- Sequence-Structure-Property Relationships in Short-Chain Polyesters: How Primary Structure Governs Macroscopic Performance.Macromolecules · 2026Article
- Lifecycle of dynamic covalent polar-olefin macrocycles via entropy-driven ring-opening polymerization and closed-loop chemical recycling.National science review · 2025Article
- One-pot synthesis of sequence-controlled macromonomersChemical science · 2025Article
- Performance-Guided Design of Chemically Recyclable Polymeric Materials: A Case Study on Thermoplastic Elastomers.ACS polymers Au · 2025Review
- Precise placement of thioester bonds into sequence-controlled polymers containing ABAC-type units.Nature communications · 2025Article
- Simple magnesium alkoxides: synthesis, molecular structure, and catalytic behaviour in the ring-opening polymerization of lactide and macrolactones and in the copolymerization of maleic anhydride and propylene oxide.Dalton transactions (Cambridge, England : 2003) · 2023Article
- Article
- A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization.Nature chemistry · 2022Article
- Green Copolymers Based on Poly(Lactic Acid)-Short Review.Materials (Basel, Switzerland) · 2021Review
- Degradable polymers via olefin metathesis polymerization.Progress in polymer science · 2021Article
- 'Sacrificial' supramolecular assembly and pressure-induced polymerization: toward sequence-defined functionalized nanothreads.Chemical science · 2020Article
- Alternating Cascade Metathesis Polymerization of Enynes and Cyclic Enol Ethers with Active Ruthenium Fischer Carbenes.Journal of the American Chemical Society · 2020Article
- Alternating Ring-Opening Metathesis Polymerization Provides Easy Access to Functional and Fully Degradable Polymers.Macromolecules · 2020Article
- Metallo-Polyelectrolytes: Correlating Macromolecular Architectures with Properties and Applications.Trends in chemistry · 2020Article
- Orthogonal functionalization of alternating polyesters: selective patterning of (AB)Chemical science · 2019Article
- Resonance promoted ring-opening metathesis polymerization of twisted amides.Chemical science · 2019Article
- Modular Approach to Degradable Acetal Polymers Using Cascade Enyne Metathesis Polymerization.Angewandte Chemie (International ed. in English) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The bulk properties of a copolymer are directly affected by monomer sequence, yet efficient, scalable, and controllable syntheses of sequenced copolymers remain a defining challenge in polymer science. We have previously demonstrated, using polymers prepared by a step-growth synthesis, that hydrolytic degradation of poly(lactic- co-glycolic acid)s is dramatically affected by sequence. While much was learned, the step-growth mechanism gave no molecular weight control, unpredictable yields, and meager scalability. Herein, we describe the synthesis of closely related sequenced polyesters prepared by entropy-driven ring-opening metathesis polymerization (ED-ROMP) of strainless macromonomers with imbedded monomer sequences of lactic, glycolic, 6-hydroxy hexanoic, and syringic acids. The incorporation of ethylene glycol and metathesis linkers facilitated synthesis and provided the olefin functionality needed for ED-ROMP. Ring-closing to prepare the cyclic macromonomers was demonstrated using both ring-closing metathesis and macrolactonization reactions. Polymerization produced macromolecules with controlled molecular weights on a multigram scale. To further enhance molecular weight control, the macromonomers were prepared with cis-olefins in the metathesis-active segment. Under these selectivity-enhanced (SEED-ROMP) conditions, first-order kinetics and narrow dispersities were observed and the effect of catalyst initiation rate on the polymerization was investigated. Enhanced living character was further demonstrated through the preparation of block copolymers. Computational analysis suggested that the enhanced polymerization kinetics were due to the cis-macrocyclic olefin being less flexible and having a larger population of metathesis-reactive conformers. Although used for polyesters in this investigation, SEED-ROMP represents a general method for incorporation of sequenced segments into molecular weight-controlled polymers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.