Evidence map›Paper›PMID 30714679›Full record

ArticleCancer medicine2019

Circular RNA expression profiles of peripheral blood mononuclear cells in hepatocellular carcinoma patients by sequence analysis.

Bo Lei, Jian Zhou, Xiuyun Xuan, Zhiqiang Tian, Mengjie Zhang, Weiwu Gao, Yuxin Lin, Bing Ni, Hui Pang, Weiping Fan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  9. Circular RNAs in hepatocellular carcinoma: Recent advances.World journal of gastrointestinal oncology · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Emerging roles of circular RNAs in liver cancer.JHEP reports : innovation in hepatology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Bo LeiDepartment of Microbiology and Immunology, Shanxi Medical University, Taiyuan, China.
Jian ZhouDepartment of Pathophysiology, Third Military Medical University, Chongqing, China.
Xiuyun XuanDepartment of Kidney, Southwest Hospital, Third Military Medical University, Chongqing, China.
Zhiqiang TianState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Mengjie ZhangDepartment of Pathophysiology, Third Military Medical University, Chongqing, China.
Weiwu GaoDepartment of Pathophysiology, Third Military Medical University, Chongqing, China.
Yuxin LinBellevue Christian High School, Bellevue, Washington.
Bing NiDepartment of Pathophysiology, Third Military Medical University, Chongqing, China.ORCID 0000-0002-4297-5346
Hui PangDepartment of Immunology, Changzhi Medical College, Changzhi, China.
Weiping FanDepartment of Microbiology and Immunology, Shanxi Medical University, Taiyuan, China.
Army Medical University · CNBellevue College · USChangzhi Medical College · CNShanxi Medical University · CNSouthwest University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a large class of noncoding RNAs that have potential regulatory roles in disease pathogenesis and progression. Recently, circRNAs have been found to be expressed in hepatocellular carcinoma (HCC) tissues and involved in the development and metastasis of HCC. However, the significance of circRNAs in peripheral blood mononuclear cells (PBMCs) of HCC patients remains unclear. In this study, RNA sequencing analysis was performed to identify circRNAs from four HCC patients and three healthy controls to determine the expression pattern of circRNAs in the PBMCs and the circRNAs' molecular regulatory networks in HCC pathogenesis. A total of 58 circRNAs were found to be significantly changed (≥2 or ≤0.5-fold) in the PBMCs of HCC patients compared with those of the healthy cases. Six random representative circRNAs (three up- and three down-regulated) were further validated by real-time RT-PCR in 72 samples of PBMCs from HCC patients and 30 control subjects. Chi-square test indicated that one of the up-regulated circRNA candidates-circ_0000798-was correlated with clinical variables. Highly expressed circ_0000798 was associated with poor overall survival of HCC patients. Receiver operating characteristic curve analysis further revealed that circ_0000798 was discriminating HCC patients from healthy controls. Finally, the predicted competing endogenous RNA network of circ_0000798 showed that it might act as a "sponge" of target microRNAs, that would subsequently regulate the expression of target genes in PBMCs. In summary, this is the first study to comprehensively identify dysregulated circRNAs in PBMCs of HCC patients, and its findings suggest that dysregulated circ_0000798 in PBMCs has potential as a convenient biomarker for diagnosing or prognosticating HCC.

Indexed as

Carcinoma, HepatocellularCase-Control StudiesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHigh-Throughput Nucleotide SequencingHumansLeukocytes, MononuclearLiver NeoplasmsMaleNeoplasm MetastasisPrognosisRNA, CircularSequence Analysis, RNASurvival AnalysisRNA, CircularbiomarkercircRNAshepatocellular carcinomahigh-throughput sequencing

Identifiers

PMID30714679
PMCPMC6488130
OpenAlexW2912514159

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.