ArticleCurrent aging science2019
Mitochondrial Common Deletion Level in Blood: New Insight Into the Effects of Age and Body Mass Index.
Article in Current aging science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- CSF Mitochondrial DNA: Biomarker of Body Composition and Energy Metabolism in Parkinson's Disease.Annals of clinical and translational neurology · 2025Article
- Mitochondrial Common Deletion Level in Adipose Tissue Is Not Associated with Obesity but Is Associated with a Structural Change in Triglycerides as Revealed by FTIR Spectroscopy.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Article
- Novel mitochondrial tRNAWorld journal of pediatrics : WJP · 2020Article
- Mitophagy and DNA damage signaling in human aging.Mechanisms of ageing and development · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge-related decrease in mitochondrial activity has been reported in several tissues. Reactive Oxygen Species (ROS) produced from defected mitochondria lead to aging and accumulate through time. However, studies about the mitochondrial DNA mutation level in blood are contradictory. Other lifestyle factors may modify the effects of age in post-mitotic tissues such as blood. The BMI represents the sum of the various lifestyle factors.
objectiveWe proposed that age, obesity and mtDNA deletion are three ROS producing factors, which may interact with each other and induce senescence.
methodsIn a cross-sectional study, 172 male and female volunteers without known mitochondrial diseases were selected and the presence of common mitochondrial 4977bp deletion (ΔmtDNA4977) evaluated using Nested-PCR.
resultsOur results showed that a high percentage of samples (54.06%) harbor common deletion in blood. Furthermore, both BMI and the ΔmtDNA4977 levels significantly decrease with age. The chronological age, BMI and ΔmtDNA4977 reciprocally affect each other.
conclusionOur data suggest that age affects purifying selection and BMI, which may influence the relative level of the mtDNA common deletion in blood.
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