Evidence map›Paper›PMID 30714249›Full record

ArticleInternational journal of methods in psychiatric research2019

Comparing opium tincture and methadone for medication-assisted treatment of patients with opioid use disorder: Protocol for a multicenter parallel group noninferiority double-blind randomized controlled trial.

Mohammadali Nikoo, Ehsan Moazen-Zadeh, Nooshin Nikoo, Sanam Javidanbardan, Alireza Kazemi, Fiona Choi, Marc Vogel, Ali Gholami, Saeed Tavakoli, Reza Givaki and 8 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of methods in psychiatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02502175 (Comparing Opium Tincture), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02502175 phase3completednot on this map

Comparing Opium Tincture (OT) and Methadone for Medication-assisted Treatment of Opioid Use Disorder: A Randomized Double-blind Controlled Clinical Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2017 to 2018Enrolled204ConditionsOpioid DependenceArmsopium, methadone
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 4 countries.

Mohammadali NikooAddiction and Concurrent Disorders Group, Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Ehsan Moazen-ZadehAddiction and Concurrent Disorders Group, Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry, University of British Columbia, Vancouver, Canada.ORCID 0000-0003-0846-1402
Nooshin NikooAddiction and Concurrent Disorders Group, Institute of Mental Health, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Sanam JavidanbardanAddiction and Concurrent Disorders Group, Institute of Mental Health, Department of Psychiatry, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-2936-4014
Alireza KazemiAddiction and Concurrent Disorders Group, Institute of Mental Health, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Fiona ChoiAddiction and Concurrent Disorders Group, Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Marc VogelDepartment of Psychiatry (UPK), Division of Addictive Disorders, University of Basel, Basel, Switzerland.
Ali GholamiKian Methadone Maintenance Treatment Clinic, Private Practice and Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.
Saeed TavakoliRooz-e-No Methadone Maintenance Treatment Clinic, Private Practice and Shiraz University of Medical Sciences, Shiraz, Fars, Iran.
Reza GivakiPsychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Majid JazaniSales, Marketing, Export, and Medical Department, Darou Pakhsh Pharmaceutical Mfg.Co., Tehran, Iran.
Fatemeh MohammadianPharmacovigilance & Clinical Trial Manager, Darou Pakhsh Pharmaceutical Mfg Co., Tehran, Iran.
Nader Markazi MoghaddamDepartment of Health Management and Economics, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Nasser GoudarziDepartment of Psychology, AJA University of Medical Sciences, Tehran, Iran.
Christian SchutzInstitute of Mental Health, Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Kerry JangInstitute of Mental Health, Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Shahin AkhondzadehPsychiatric Research Center, Roozbeh Hospital, Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran.
Michael KrauszAddiction and Concurrent Disorders Group, Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
University of British Columbia · CACentre for Addiction and Mental Health · CAAja University of Medical Sciences · IRAmerican Pharmacists Association · USIsfahan University of Medical Sciences · IRMazandaran University of Medical Sciences · IRRoozbeh Hospital · IRShiraz University of Medical Sciences · IRTehran University of Medical Sciences · IRUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis is the first study to compare the safety and efficacy of opium tincture (OT) with methadone for treatment of opioid use disorder.

methodsIn this multicenter, double-blind, noninferiority controlled trial, a stratified sample of 204 participants with opioid use disorder were recruited from community outreach, drop-in centers, and triangular clinics. Participants were excluded in case of active participation in another treatment program for opioid use disorder, hypersensitivity to trial medications, pregnancy, and certain serious medical conditions. They were randomized to receive either OT or methadone with an allocation ratio of 1:1 using a patient-centered flexible dosing strategy. Eligible participants were followed for a period of 12 weeks. Primary outcome is the difference in percentage of patients retained in the treatment. Secondary outcomes are craving, withdrawal symptoms, physical health, mental health, quality of life, and severity of substance use problems, cognitive function, safety profile, cost-effectiveness, and participants' satisfaction. Both intention-to-treat and per-protocol analyses will be conducted. The Ethics Board of the University of British Columbia and Tehran University of Medical Sciences approved the study. (clinicaltrials.gov; NCT02502175).

resultsTo be reported after final analysis.

conclusionsIf shown to be effective, OT will diversify the options for medication-assisted treatment of opioid use disorder.

Indexed as

MethadoneOpiate Substitution TreatmentOpioid-Related DisordersOpiumAdultDouble-Blind MethodEquivalence Trials as TopicFemaleHumansMaleMulticenter Studies as TopicRandomized Controlled Trials as TopicMethadoneOpiumclinical trialmethadoneopioidopiumsubstance use

Identifiers

PMID30714249
PMCPMC6877259
OpenAlexW2911242260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.